# Clinical Science Research Core (CSRC)

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2020 · $304,479

## Abstract

PROJECT SUMMARY/ABSTRACT- Clinical Science Research Core:
The Clinical Science Research Core (CSRC) enhances and facilitates nutrition/obesity-related clinical and
translational research by assisting investigators in conducting studies in human subjects through the operation
of two sub-cores. The Clinical Studies Performance sub-core facilitates clinical research by assistance with: i)
subject recruitment, ii) planning and performance of clinical studies (i.e., a diverse array of tracer and non-
tracer protocols such as the hyperinsulinemic-euglycemic clamp procedure, multi-tracer meal tests,
intravenous and oral glucose tolerance tests, and arterial venous balance studies, to assess substrate and
insulin kinetics), iii) body composition assessments [by using dual energy X-ray absorptiometry (DEXA),
BodPod, Peapod, magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS)], iv)
mixing of intravenous tracer and hormone solutions, v) acquisition of tissue (adipose, muscle, intestine) biopsy
samples, vi) exercise (endurance and strength) and physical performance testing, vii) indirect calorimetry, viii)
lifestyle (diet manipulation, behavioral therapy, exercise training, and weight loss/weight gain) interventions, ix)
ingestive behavior (taste perception and preference) testing, and x) cardiovascular assessments (e.g.,
echocardiography, endothelial function, carotid artery intima-media thickness). The Metabolic Kinetics sub-
core provides comprehensive services and training to study diverse areas of metabolic function, including: i)
design of tracer and non-tracer protocols to evaluate in vivo substrate kinetics (e.g. glucose and fatty acid flux,
VLDL-triglyceride secretion rate), insulin sensitivity, insulin secretion rates, and -cell function, ii) sample
processing and measurement of stable isotope enrichment of metabolic substrates in blood, tissue, and
primary human tissue culture samples, and iii) mathematical modeling of tracer and non-tracer data for the
assessment of metabolic kinetics, insulin sensitivity, insulin secretion rates, and -cell function. In addition, the
CSRC provides training for investigators, their staff, and research fellows in these areas of clinical research,
both in the form of one-on-one hands-on instruction as well as through seminars and lecture series.
Combining these services within one Core provides a cohesive organizational structure that facilitates the
performance of complex clinical research studies, fosters interdisciplinary collaborations between NORC
investigators, and reduces the barriers for basic scientists, and non-physician and young investigators who
wish to conduct clinical research. The CSRC also ensures that all studies and procedures that are supported
by the core are conducted in compliance with federal and local (state and hospital) regulations regarding
research involving human subjects.

## Key facts

- **NIH application ID:** 9926265
- **Project number:** 5P30DK056341-20
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Bettina Mittendorfer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $304,479
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9926265

## Citation

> US National Institutes of Health, RePORTER application 9926265, Clinical Science Research Core (CSRC) (5P30DK056341-20). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/9926265. Licensed CC0.

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