# Adipocyte Biology and Molecular Nutrition (ABMN)

> **NIH NIH P30** · WASHINGTON UNIVERSITY · 2020 · $155,998

## Abstract

PROJECT SUMMARY/ABSTRACT – Adipocyte Biology and Molecular Nutrition Core
Coordination of substrate use between key metabolic tissues such as adipose, muscle and liver is essential for
energy homeostasis, insulin sensitivity and overall health. Adipose tissue is central to energy regulation with
roles in fuel storage and mobilization, and the secretion of factors (i.e. adipokines) that influence food intake,
energy expenditure, and the functioning of key organs such as the vasculature, muscle and liver. Obesity-
induced expansion of adipose tissue often associates with metabolic dysfunction, systemic inflammation, and
comorbid diseases such as cardiovascular disease, diabetes and cancer. The purpose of the Adipocyte
Biology and Molecular Nutrition (ABMN) Core, established in 2006, is to foster and facilitate research related to
pathways influencing adipose tissue structure/function and the function of other key metabolic tissues such as
muscle and liver. The Core provides researchers with cost-effective access to specialized equipment, expert
training and reliable services that are not easily available elsewhere at Washington University. The centralized
provision of targeted and specialized high quality services by the ABMN Core increases efficiency of research
efforts and reduces barriers for clinical and young investigators who wish to conduct sophisticated nutrition-
related research but do not have the expertise or facilities/equipment within their own programs. The ABMN
Core is interactive and tries whenever possible to tailor services to meet the needs of NORC investigators. The
ABMN Core provides the following services: 1) Cell lines (mouse and human pre-adipocytes and myoblasts)
and culture protocols; 2) Adipose tissue phenotyping (cell sizing, macrophage infiltration/polarization, and
fibrosis); 3) Optimized tissue lysis, RNA isolation, gene and protein expression for nutrition/obesity related
targets; 40 Mitochondrial physiology of tissues or isolated mitochondria; 5) Cell biology and organelle imaging
to visualize substrate processing e.g. lipid deposition/trafficking; 6) Access to specialized equipment; and 7)
Consultation and training provided by the Core leadership and staff with strong synergistic expertise in
molecular research in nutrition and obesity.

## Key facts

- **NIH application ID:** 9926270
- **Project number:** 5P30DK056341-20
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Nada A. Abumrad
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $155,998
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9926270

## Citation

> US National Institutes of Health, RePORTER application 9926270, Adipocyte Biology and Molecular Nutrition (ABMN) (5P30DK056341-20). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/9926270. Licensed CC0.

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