# Chemical Analysis Facility Core

> **NIH NIH P30** · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $161,034

## Abstract

ABSTRACT: CHEMICAL ANALYSIS FACILITY CORE
Accurate and sensitive qualitative and quantitative determination of toxicants forms a core element of CEED’s
mission. The Chemical Analysis Facility Core (CAF) maintains state-of-the-art measurement capabilities to
identify and quantify levels of chemicals in the total environment; characterizing potential internal dose (from
environmental matrices), metabolites and biologically effective doses in target tissues. The goal of this Facility
Core is to provide Center investigators assistance in experimental design, sample preparation, assay
development, training, and access to technologies. These analysis tools are necessary for accurate
assessment of chemical exposures for targeted metabolite analyses (biological response indicators) that can
be linked to mechanisms of pathogenesis. Analysis of toxicants and their metabolites in a variety of biological
and environmental matrices (e.g., blood, urine, sputum, cellular extracts, water, soil, dust) is performed within
the CAF using mass spectrometrically-based techniques. The CAF also generates detailed mechanistic and
metabolomic information on toxicants and chemo preventive or therapeutic agents and supports rapid
response initiatives and new sensor development. The CAF uses inductively- coupled plasma mass
spectrometry (ICPMS) for the bulk of its elemental analysis, gas chromatography/mass spectrometry (GC/MS)
for semi-volatile and volatile molecular analytes, and high/ultra-performance liquid chromatography/mass
spectrometry (HPLC/MS) for nonvolatile and polar chemical analysis. Through University funding (see
Facilities and Resources section) the CAF continues to expand its capacities in metabolomics for discovery of
biomarkers that bridge exposure to resultant biological responses and, ultimately, disease pathogenesis.

## Key facts

- **NIH application ID:** 9927645
- **Project number:** 5P30ES005022-33
- **Recipient organization:** RBHS-SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** BRIAN T BUCKLEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $161,034
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9927645

## Citation

> US National Institutes of Health, RePORTER application 9927645, Chemical Analysis Facility Core (5P30ES005022-33). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9927645. Licensed CC0.

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