# Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-Old

> **NIH NIH P01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $405,592

## Abstract

Project-2 Summary/Abstract:
The prevalence of Alzheimer's disease (AD) is closely related to the presence
of cardiovascular disease (CaVD), understanding the relationship between AD pathology and CaVD is critically
important. In the competing renewal of this Program Project (PPG3), we will explore whether our finding
related to CaVD and Aβ pathology in a very elderly cohort will apply to a more diverse cohort. The overarching
goal of Project 2 of PPG3 is to further the understanding of the relationship between AD pathology and midlife
CaVD and the impact of these factors on cognitive impairment in a group of young old. To achieve these goals,
we will utilize a group non-demented participants from an existing cohort from the ongoing community-based
Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in
2003 with a cohort of 2000 participants (43% African American) between the ages of 45-75 years at study
entry and has collected a wealth of longitudinal vascular measures. This study will explore two main
hypotheses explore two hypotheses: 1) CaVD and amyloid-beta (Aβ) deposition are independent predictors of
cognitive decline, and increased CaVD creates a state of vulnerability by interfering with vascular-related
compensatory mechanisms; and 2) CaVD accelerates Aβ deposition in the brain, thus accelerating the onset
of clinical symptoms. The findings from this study will help to further inform our understanding of the
relationship between vascular pathology and AD pathology in midlife.

## Key facts

- **NIH application ID:** 9927987
- **Project number:** 5P01AG025204-15
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Ann D. Cohen
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $405,592
- **Award type:** 5
- **Project period:** — → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9927987

## Citation

> US National Institutes of Health, RePORTER application 9927987, Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-Old (5P01AG025204-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9927987. Licensed CC0.

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