# Evaluating Disease Progression in Hip Osteoarthritis

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $684,233

## Abstract

ABSTRACT
The overall goal of this proposal is to evaluate cartilage composition of patients with hip osteoarthritis (OA)
using advanced MRI techniques, and determine their relationship to development of cartilage lesions, patient
function, and changes in hip kinematics and kinetics during functional tasks. The central hypothesis is that
early changes in cartilage biochemistry and altered hip biomechanics are associated with progression of hip
OA defined by worsening patient-reported outcomes and higher cartilage lesion scores. To accomplish this we
need to establish the cross-sectional relationship of these metrics and natural history of hip OA over three
years with the following specific aims: Aim I) To characterize hip cartilage T1ρ and T2 relaxation time, their
spatial heterogeneity and anatomical location, and association of hip geometry (i.e. alpha angle, acetabular
depth, etc), as a function of (I.A) KL grade and (I.B) annual follow-up time (Years 0-3); Aim II) To determine the
relationship between hip cartilage composition (measured by MR T1ρ and T2 relaxation time, spatial
heterogeneity, their anatomical location - Aim I outcomes) and disease progression as measured by (IIA) hip
joint morphology (see Fig. 1- semi-quantitative MR grading1, adjusted for hip geometry such as alpha angle)
and (IIB) patient reported outcomes (as determined by HOOS15); and Aim III) To determine the relationship
between hip cartilage composition (measured by MRI T1ρ and T2 relaxation time, Aim I outcomes), and sagittal
plane hip kinematics and kinetics during functional tasks (peak hip flexion angle and peak hip extension
moments during gait, stairs, and sit-to-stand). A total of 144 hips across a range of OA severity will be included
in the study. Advanced quantitative imaging, motion analysis, and functional testing will be performed annually
over three years (baseline, 1, 2, and 3 year follow-up). This comprehensive evaluation of the associations of
hip cartilage relaxation times, lesion prevalence, and biomechanics is the vital first step to determine the
natural history of hip OA using non-invasive assessment. This information forms the crux of what is needed to
design and assess the effectiveness of conservative (gait retraining, muscle strengthening), disease modifying
drugs, and surgical (femoral and pelvic osteotomy, etc.) interventions at slowing or reversing the disease
process.

## Key facts

- **NIH application ID:** 9928007
- **Project number:** 5R01AR069006-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Sharmila Majumdar
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $684,233
- **Award type:** 5
- **Project period:** 2016-07-14 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9928007

## Citation

> US National Institutes of Health, RePORTER application 9928007, Evaluating Disease Progression in Hip Osteoarthritis (5R01AR069006-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9928007. Licensed CC0.

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