Muller glia heterogeneity and progenitor fate

NIH RePORTER · NIH · R01 · $312,000 · view on reporter.nih.gov ↗

Abstract

Blinding eye diseases are among the most feared disabilities afflicting the human population. Macular degeneration and glaucoma are the leading causes of blindness in the USA. These diseases result from neurodegeneration. Although a number of strategies for restoring sight to the blind are being pursued, a regenerative one may be most ideal. Unfortunately mammals do not regenerate their CNS. However, hope comes from zebrafish that posess remarkable regenerative powers and can regenerate a damaged retina. The zebrafish retina shares structure and function with the mammalian retina and therefore, is an ideal system for studying retina regeneration. Key to the success of retina regeneration in zebrafish are Muller glia (MG) that respond to retinal damage by adopting properties of a stem cell that allows them to divide and generate progenitors for retinal repair. It appears that fish MG are more plastic than their mammalian counterparts and this plasticity allows them to acquire a stem cell-like state in response to retinal damage. This plasticity may be influenced by intrinsic mechanisms and also the enviroment MG reside in. Our studies investigates interactions between MG and their environment and how this impacts their quiescence and proliferation. In addition, MG may represent a heterogenous population of which some are more prone to participate in retinal repair than others. Our studies investigate MG heterogeneity and its impact on retina growth and regeneration. Finally, although the ability of zebrafish MG to regenerate neurons is well documented, little is known about the integration and function of these regenerated neurons in the retinal circuitry. Our studies will investigate regenerated neuron integration into preexisting visual circuits and their participation in phototransduction. These studies will not only further our understanding of MG plasticity and neuronal regeneration in zebrafish, but will also suggest new strategies for stimulating retina regeneration in mammals.

Key facts

NIH application ID
9928928
Project number
5R01EY027310-04
Recipient
UNIVERSITY OF MICHIGAN AT ANN ARBOR
Principal Investigator
DANIEL J GOLDMAN
Activity code
R01
Funding institute
NIH
Fiscal year
2020
Award amount
$312,000
Award type
5
Project period
2017-09-01 → 2021-05-31