# FHFs and Cardiac Electrophysiology

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $798,465

## Abstract

PROJECT SUMMARY
Heart disease remains the leading cause of death in the United States and other developed countries. Half of
these deaths occur suddenly, typically from ventricular tachyarrhythmias that arise in the setting of acute
ischemia, acquired heart disease or inherited syndromes including channelopathies and cardiomyopathies.
Despite decades of research, major gaps exist in our understanding of the molecular mechanisms responsible
for normal cardiac rhythmicity, as well as abnormalities that increase the risk of rhythm disturbances. Our
laboratory has identified molecules, known as fibroblast growth factor homologous factors (FHFs), that potently
regulate heart rhythm. In the absence of FHFs, hearts develop significant conduction disease and arrhythmias.
In this application we propose a series of experiments designed to understand the mechanisms through which
deficiency of FHF proteins results in these disease manifestions.

## Key facts

- **NIH application ID:** 9929433
- **Project number:** 5R01HL142498-03
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Glenn I Fishman
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $798,465
- **Award type:** 5
- **Project period:** 2018-08-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9929433

## Citation

> US National Institutes of Health, RePORTER application 9929433, FHFs and Cardiac Electrophysiology (5R01HL142498-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9929433. Licensed CC0.

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