# Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES)

> **NIH NIH R01** · KAISER FOUNDATION RESEARCH INSTITUTE · 2020 · $394,642

## Abstract

Abstract
We propose a retrospective cohort study of > 5 million adult members of Kaiser Permanente Northern California
during 2000 to 2015, linked to state-of-the-art exposure estimates of fine particulate matter <2.5 μm in diameter
(PM2.5) generated at 1km x 1km resolution using a novel hybrid model that incorporates meteorologic, land-use
and satellite measures. By combining these high-resolution PM2.5 exposure estimates with our rich clinical data
source in this high-powered study, we will achieve the following Aims. In a cohort of subjects who have no
preexisting CVD, we will quantify the associations between ambient PM2.5 exposure and risk of incident CVD
events in order to determine whether demographic characteristics (age, sex, race/ethnicity, and SES) and clinical
comorbidities (obesity, diabetes, hypertension, and hyperlipidemia) are susceptibility factors that confer elevated
risk to the effects of PM2.5. In a cohort of subjects who have a history of CVD, we will quantify the associations
between ambient PM2.5 exposure and risk of a subsequent CVD event during follow-up in order to determine
whether history of CVD is a susceptibility factor and whether susceptibility varies by particular CVD conditions,
and to determine whether demographic characteristics and clinical comorbidities are susceptibility factors that
confer elevated risk of the effects of PM2.5 with CVD events. This study provides insights no other cohort or
administrative database can address; we are uniquely able to address the question of susceptibility to air
pollution because of a convergence of state-of-the-art modeling of PM2.5 exposures at high-resolution, geocoded
data, and detailed electronic medical record data that captures time-varying comorbidities, clinical encounters,
laboratory and pharmacy data, unavailable in virtually any other population.

## Key facts

- **NIH application ID:** 9929583
- **Project number:** 5R01ES029557-03
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Stacey E Alexeeff
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $394,642
- **Award type:** 5
- **Project period:** 2018-09-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9929583

## Citation

> US National Institutes of Health, RePORTER application 9929583, Particulate Air Pollution, Cardiovascular Events, and Susceptibility Factors (PACES) (5R01ES029557-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9929583. Licensed CC0.

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