# Optimizing Atrial Fibrillation Management in CKD

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $781,528

## Abstract

ABSTRACT
Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting >33.5 million adults world-
wide, with the highest rates in North America. Chronic kidney disease (CKD) is also highly prevalent and
affects 14% of the U.S. and North American population. The burden of AF is 3-fold higher in CKD and affects
up to 25% of CKD patients. AF is linked to poor outcomes. Our data demonstrate that among patients with
CKD, incident AF is associated with a 3-to-7-fold greater risk of heart failure (HF), acute coronary syndromes
(ACS), stroke, death and progression to end-stage renal disease (ESRD) vs. CKD patients without AF. Despite
the high risks associated with AF, it is unknown whether AF therapies improve outcomes in the setting of CKD.
The unique pathophysiology of AF in CKD, the effects of decreased renal clearance, as well as competing
risks of non-AF related death may alter the effectiveness and safety of commonly used AF medications and
procedures in CKD. To our knowledge, no published studies have evaluated the collective influence of AF
therapies on kidney and cardiovascular outcomes in CKD. Trials of AF therapies have largely excluded
patients with CKD. Prior observational studies have several notable limitations: (1) focus only on warfarin and
not a comprehensive evaluation of other AF therapies; (2) focus only on stroke and death as outcomes; and (3)
inadequate consideration of interim clinical measures that may affect receipt and outcomes of AF therapies.
Our overall goal is to use "real-world" contemporary data to evaluate the risks vs. benefits of various AF
therapies, including medications and procedures, in adults with CKD. We will perform a comparative
effectiveness analysis to delineate whether treatment of AF impacts important kidney and cardiovascular
outcomes in patients with vs. without CKD. To conduct these aims, we will use the Cardiovascular Research
Network (CVRN) platform to study a community-based network of ~267,000 patients with AF from two
participating health care systems in California; and we will externally validate these findings in a community-
based cohort of ~392,000 patients in Ontario, Canada. We will evaluate the use, response and safety of
current AF therapies (including anticoagulation, rate control agents, anti-arrhythmic agents and AF-related
procedures) in patients with vs. without CKD. We will perform a comparative effectiveness analysis to delineate
whether treatment of AF impacts important kidney and cardiovascular outcomes in patients with vs. without
CKD. The data from this study may provide guidance for an integrated AF management approach to improve
clinical outcomes in CKD and inform the design of future trials of patients with AF and CKD.

## Key facts

- **NIH application ID:** 9930120
- **Project number:** 5R01HL142834-02
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Nisha Bansal
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $781,528
- **Award type:** 5
- **Project period:** 2019-06-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9930120

## Citation

> US National Institutes of Health, RePORTER application 9930120, Optimizing Atrial Fibrillation Management in CKD (5R01HL142834-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9930120. Licensed CC0.

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