# Core C Clinical Core

> **NIH NIH P30** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $353,397

## Abstract

PROJECT SUMMARY
Clinical Core (Core C)
Situated in the Deep South, with prominent footing in rural communities in Alabama and adjacent states, the
UAB CFAR Clinical Core (Core C) is uniquely positioned to support scientific inquiries at the interface of
prevention and treatment, clinic and community, to hasten an end to HIV/AIDS via the following Specific Aims:
1. To provide Computerized Database and Informatics Services, 2. To provide a comprehensive and efficient
Specimen Repository obtained from well-characterized persons living with HIV (PLWH), 3. To provide Study
Coordination Services, and 4. To provide comprehensive Biostatistical and Epidemiological Services. Core
C has been a cornerstone of the UAB CFAR since its inception, with the UAB 1917 HIV/AIDS Clinic (1917 Clinic)
as its focal point. Functioning as a learning healthcare system, observations made at the point of clinical care
have driven the scientific initiatives supported by Core C, aligned with the overarching CFAR mission, since
1988. The pursuit of knowledge to address clinically relevant questions has fueled discovery and scholarship
that has fed back to the 1917 Clinic to enhance service delivery and treatment outcomes for PLWH, with broad
impact nationally and globally. During the last 5-year funding period, Core C generated 780 analysis ready
datasets, processed 152,000 specimen vials, and captured 10,800 patient reported outcomes survey
assessments at the point of care, while supporting 70 extramural grants and publication of over 300 peer-review
manuscripts. A noteworthy milestone, the Clinical Core supported 12 early stage investigators (ESI) from UAB
and an additional 10 ESI from other CFARs during the last funding period, who were collectively awarded 15
career development awards (including 11 K awards) and 4 first R01 awards.
With a census of roughly 3,500 PLWH, disproportionately African Americans and men who have sex with men,
the 1917 Clinic remains the focal point of Core C. However, Clinical Core leadership extends beyond the 1917
Clinic to cultivate unique research platforms via the Jefferson County HIV/AIDS Community Coalition and
Alabama Quality Management Group that includes nine HIV clinics statewide providing care for over 6,800
PLWH. Core C innovations include integration of Biostatistical and Epidemiological Services to facilitate
synergies and efficiencies, roll out of a user-friendly, web-based REDCap Common Request Form to solicit any
(or multiple) core services, and the addition of a Phylogenetic Analysis Database, and Geospatial Database to
inform and augment HIV prevention and treatment science. Core C plays a pivotal role enhancing intra- and
inter-CFAR collaborations, providing vital research support and leadership to our Interdisciplinary Research
Groups and newly formed Ending HIV in Alabama Scientific Working Group, and leveraging synergies with other
research Centers, notably the Center for Clinical and Translational Science (UAB CTSA). Ultima...

## Key facts

- **NIH application ID:** 9930530
- **Project number:** 5P30AI027767-32
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** MICHAEL J MUGAVERO
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $353,397
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9930530

## Citation

> US National Institutes of Health, RePORTER application 9930530, Core C Clinical Core (5P30AI027767-32). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9930530. Licensed CC0.

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