# Nonhuman Primate Reagent Resource

> **NIH NIH U24** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $1,769,004

## Abstract

Nonhuman primates (NHPs) serve a crucial role in translational research as animal models
for exploring the pathogenesis of infectious and noninfectious diseases, and for testing of
biologic therapies and vaccines. While many human diagnostic immunologic reagents cross
react with the primate species commonly employed in translational research, gaps exist for a
substantial number of reagent targets. Furthermore, antibodies that target specific immune
functions or deplete specific lymphocyte subpopulations in vivo have proven valuable in
defining disease mechanisms or can be used as proof-of-concept for new therapies.
For the past 15 years, the NIH Nonhuman Primate Reagent Resource has responded to
needs of the scientific community by developing, manufacturing and distributing NHP-
specific reagents for in vitro diagnostics and for in vivo use. Utilization of this resource has
grown dramatically since this program's inception. During the last budget year, we fulfilled
500 reagent requests from 126 investigators and distributed over 300 grams of recombinant
antibody for administration to NHPs.
Taking advantage of scientific advances and technological improvements in antibody
development, engineering, expression and vectoring, we will continue to support the
scientific community utilizing NHP models across all scientific disciplines.

## Key facts

- **NIH application ID:** 9931151
- **Project number:** 5U24AI126683-05
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Kathleen Engelman
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,769,004
- **Award type:** 5
- **Project period:** 2016-09-29 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9931151

## Citation

> US National Institutes of Health, RePORTER application 9931151, Nonhuman Primate Reagent Resource (5U24AI126683-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9931151. Licensed CC0.

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