# Systems Analysis of Epigenomic Architecture in Cancer Progression

> **NIH NIH U54** · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2020 · $217,617

## Abstract

ABSTRACT/SUMMARY - Administrative Core
The goals of the Administrative Core are to provide streamline governance of our center and to promote
collaboration and integration among experimental and computational researchers. The leadership will be
responsible for the oversight and effective management of the Core in order to enhance intra- and inter-center
communication and to facilitate data dissemination through the NCI's Research Center for Cancer Systems
Biology (RCCSB) Consortium. The Executive Committee (EC) is consisted of eight members who are leaders
of three projects and three cores. These EC members will monitor monthly progress of omics studies and
outreach/training activities, conduct scientific reviews of Intra-center Pilot Project (IPP) applications, and
prioritize access to high-performance computing servers and to biospecimens including primary tumors,
patient-derived xenograft (PDX) lines, and circulating tumor cells. A four-member panel of Internal Advisory
Board (IAB) will meet quarterly to provide ongoing feedback and to advise new directions of cancer omics
research within our center. To foster innovative ideas of cancer omics research, the Administrative Core will
encourage IPP applications from mathematicians, computer scientists, engineers, and biophysicists who are
interested in interfacing with biomedical researchers in participating institutions. Prior evidence of omics
research is not necessary for submission of a proposal although an eventual avenue for integrative and
translational applications should be apparent. Funding of IPPs is supported in part by the proposed RCCSB
budget and matching funds from the Alice P. McDermott Endowment at the University of Texas Health Science
Center at San Antonio. A robust and transparent peer review process will be established to evaluate submitted
proposals and to regularly review the progress of funded proposals. In addition, two mentors – one
experimentalist and one computational modeler will be assigned to each junior awardee to instill the concept of
team-oriented research and to monitor career development of the awardee in systems biology. The leadership
of this Core will recruit four prominent scientists from outside of our center with expertise in 4D nucleome,
omics data integration, or anti-hormone therapy. These External Advisory Board (EAB) members will
independently conduct annual reviews of all aspects of our intra- and inter-center research activities, including
experimental designs, statistical and mathematical approaches, translational applications, mentoring and
outreach training, and administrative effectiveness. The EAB will provide recommendations regarding
continuation and alterations of specific sub-aims or objectives of each project and core. Other
recommendations by EAB are expected to expand the horizon of our cancer omics research. Thus, through
these administrative mechanisms the Core will promote high-quality, team-oriented, and niche-focused
research in o...

## Key facts

- **NIH application ID:** 9931172
- **Project number:** 5U54CA217297-04
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- **Principal Investigator:** Tim H.-M. Huang
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $217,617
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9931172

## Citation

> US National Institutes of Health, RePORTER application 9931172, Systems Analysis of Epigenomic Architecture in Cancer Progression (5U54CA217297-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9931172. Licensed CC0.

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