# Basic Science Core II

> **NIH NIH P30** · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $286,457

## Abstract

SUMMARY
Basic Science Core II (BSCII) focuses on in vivo and translational aspects of basic neuroscience and
encompasses animal models and their behavioral testing, histology, microscopy, neuropathology, and
neuronal functional studies. The BSCII assists investigators with animal models and behavioral testing allowing
them to overcome the challenges of developing and characterizing new rodent models, particularly with
behavioral phenotypes, which may be outside their areas of expertise. The core offers several models of
neuroAIDS, including immunodeficient mouse models of HIV encephalopathy, in vivo HIV-1 infection using
humanized mice, transgenic models including the HIV Tg26 transgenic mouse and the GFAP-Tat Tet-inducible
transgenic mouse, inducible and tissue specific transgenic, knockdown, or knockout models, cell
transplantation models, viral vector delivery, etc. Expertise in behavioral testing for cognitive changes in
learning and memory, as well as peripheral neuropathies are provided. Expertise in the core includes
experience in breeding and phenotyping of neurological models, and neurobehavioral testing which can be
particularly challenging for investigators without prior experience. Assistance is also provided with histological
and immunohistochemical evaluation of human autopsy and biopsy clinical samples from patients with
neurological disorders, including AIDs, PML, neurodegenerative diseases, and CNS neoplasia, tissues
harvested from experimental animal models, cell cultures and access to neuropathological consultation. The
core provides study design and data interpretation, and microscopy services, including Laser Capture
Microdissection (LCM) accessioning of tissue samples and nucleic acid extraction for downstream molecular
biological applications, quantitative microscopy and imaging, and data analysis. We also offer state-of-the-art
microelectrode array (MEA) studies for neuronal function in cell culture and whole animal systems. A key
component of the core is to provide the necessary training to the investigators and their staff to gain the
proficiency needed to independently conduct any of the routine core functions. These services assist
investigators in the neuroAIDS community with an array of histopathological and in vivo translational
resources.

## Key facts

- **NIH application ID:** 9931311
- **Project number:** 5P30MH092177-10
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Jennifer Gordon
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $286,457
- **Award type:** 5
- **Project period:** — → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9931311

## Citation

> US National Institutes of Health, RePORTER application 9931311, Basic Science Core II (5P30MH092177-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9931311. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*