# PITT-CAL ETCTN PK Resource Laboratory

> **NIH NIH U24** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $531,026

## Abstract

SUMMARY
The purpose of this U24 Cooperative Agreement is to support a consortium of two National Cancer Institute
(NCI)-Designated Comprehensive Cancer Center-funded pharmacokinetic (PK) core labs that have joined
together as a consolidated, integrated PK resource for the NCI Experimental Therapeutics-Clinical Trials
Network (ETCTN). The UPMC Hillman Cancer Center (HCC) Cancer Pharmacokinetics and
Pharmacodynamics Facility and City of Hope (COH) Analytical Pharmacology Core Facility are nationally
recognized for their leadership in the pharmacological characterization of anticancer agents. The newly formed
PITT-CAL ETCTN PK Resource Laboratory (PITT-CAL) proposes to systematically evaluate the ADME profiles
of CTEP agents in various phases of clinical development through the accomplishment of the following
objectives: (1) To apply pharmacology expertise to the ETCTN early drug development efforts by assisting in
study design and other PK-related activities; (2) To analyze biological samples with quantitative assays; and
(3) To perform non-compartmental, compartmental, and population PK analyses and report the results to study
teams and CTEP in a timely manner. Our approach will be to use our technical and scientific expertise to lead
all PK-related activities and integrate these PK investigations with the other clinical and correlative studies
performed during the drug development process. We will develop, validate, and implement accurate, precise,
and sensitive assays for study drugs and metabolites in plasma, tissues and other biological samples, and
analyze clinical samples from the ETCTN LOAs. Lastly, we will derive PK parameters to characterize the
ADME of agents in ETCTN trials, integrate these results with pharmacodynamic measures of drug response
and report to CTEP and the clinical team to optimally inform ongoing and future development of CTEP agents
and their combinations.

## Key facts

- **NIH application ID:** 9932532
- **Project number:** 1U24CA247643-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Jan Hendrik Beumer
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $531,026
- **Award type:** 1
- **Project period:** 2020-05-15 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9932532

## Citation

> US National Institutes of Health, RePORTER application 9932532, PITT-CAL ETCTN PK Resource Laboratory (1U24CA247643-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9932532. Licensed CC0.

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