# Dietary Factors in Retinal Aging and Macular Disease

> **NIH NIH R01** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $457,014

## Abstract

PROJECT SUMMARY
 Age-related macular degeneration (AMD) is the most common cause of legal blindness in the elderly in
developed countries and a leading cause of blindness worldwide. A growing body of evidence supports
protective roles for nutritional factors, including the carotenoids lutein (L) and zeaxanthin (Z), which
concentrate in the fovea to form the macular pigment, and omega-3 (ω-3) fatty acids. However, the typical
American diet is low in these nutrients and therefore, there is an urgent need to better understand the role that
these nutrients play in retinal aging and disease and their potential to reduce the risk of AMD. Only nonhuman
primates with a macula and fovea provide an accurate translational model to address this issue. We have
available three exceptional resources: groups of aging macaque monkeys with life-long controlled diets devoid
of L and Z and providing either adequate or deficient ω-3 fatty acid content, and showing signs of early AMD;
aging monkeys fed diets high in fat and sugar and mimicking the typical American diet; and a large colony of
aging macaques fed a healthy diet to address the effects of normal aging. Comparison of these groups of
animals provide a truly unique opportunity to understand the roles of dietary factors in retinal aging and
disease. This proposal will use these unique resources to address the following aims:
 1) Define the relationships in vivo among macular pigment and metrics of macular health in primate
eyes across the lifespan and across a wide range of dietary histories including including life-long
absence of L/Z.
 2) Define the relationships ex vivo among L/Z, the molecular components of lipofucsin, retinal
morphology and diet-related retinal pathology, and correlate these findings to the corresponding
measurements obtained in vivo.
 Collectively, these aims will quantify longitudinal changes in macular pigment and the concentration and
distribution of components of lipofuscin in the retina and RPE, will characterize changes in retinal structure with
age and retinal disease, and will correlate these measurements between in vivo and ex vivo assessment
modalities to enhance the interpretation of in vivo imaging.
 We expect the outcome of the proposed work to have a significant impact on the understanding of the role
of macular pigment and dietary fat in aging and retinal diseases including AMD. We also expect to provide data
critical to the current controversy on the role of lipofuscin components in AMD. Our studies also will provide
exceptional opportunities to examine the evolution of retinal aging and disease, as well as to obtain high quality
clinicopathological correlations in multiple metrics of retinal health. Because of the highly translational nature
of these nonhuman primate studies, they are expected to have a significantly high impact on understanding the
role of nutrition in maintaining retinal health and prevention or treatment of retinal disease.

## Key facts

- **NIH application ID:** 9933000
- **Project number:** 5R01EY028141-03
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** MARTHA NEURINGER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $457,014
- **Award type:** 5
- **Project period:** 2018-09-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9933000

## Citation

> US National Institutes of Health, RePORTER application 9933000, Dietary Factors in Retinal Aging and Macular Disease (5R01EY028141-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9933000. Licensed CC0.

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