# Zeiss Light Sheet Z1 Microscope

> **NIH NIH S10** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $778,510

## Abstract

PROJECT SUMMARY:
A user group of seven major, NIH funded, and three minor investigators request $792,426 to purchase a Zeiss
Z1 light sheet microscope. This instrumentation and associated equipment will be housed in the Health
Science District Advanced Imaging Facility at the University of California Davis. The need for a high-resolution
microscope that can rapidly acquire data from large samples is a natural extension of the high-quality images
routinely obtained by researchers in this facility.
The needs of many researchers for fast imaging of very large volumes or live specimens are not met at any of
the core imaging facilities at UC Davis. This request would bring state of the art technology not available at UC
Davis, to a designated campus core facility. As such, we believe this microscope greatly expands the capability
of our core (and the imaging capability of this campus). This microscope will be integrated into our core facility
and its existing infrastructure will integrate the operation, maintenance and management of this instrument.
This instrumentation is intended to complement existing infrastructure and accelerate data acquisition. The
selective light sheet system from Zeiss is a sensible and cost-effective system that balances resolution, speed,
stability, well designed user interface, and ability for customization and upgradability. These attributes make
the Z1 system an ideal instrument for our academic facility.
As detailed in this proposal the availability of uniquely engineered objective lenses to allow for imaging of
samples of several refractive indices is of critical importance. The available objectives and associated
accessories allow for imaging of live tissues, organism such as zebrafish, to optically clarified tissues. This
setup has been tested by the NIH investigators that comprise the major users, and the minor users of this
instrument, and has provided exceptional images and data.
Management of this proposed instrument will be integrated into the existing successful imaging facility, which is
managed full time Dr. Ingrid Brust-Masher, and guided by a Facility director and advisory board. The HSDAIF
serves many researchers from across disciplines of study with advanced instrumentation.

## Key facts

- **NIH application ID:** 9933450
- **Project number:** 1S10OD026719-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Colin Reardon
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $778,510
- **Award type:** 1
- **Project period:** 2020-05-01 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9933450

## Citation

> US National Institutes of Health, RePORTER application 9933450, Zeiss Light Sheet Z1 Microscope (1S10OD026719-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9933450. Licensed CC0.

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