# Mouse Resources and Validation

> **NIH NIH P50** · JACKSON LABORATORY · 2020 · $221,325

## Abstract

PROJECT SUMMARY MOUSE RESOURCES AND VALIDATION CORE (CORE C)
The Mouse Resources and Validation Core (MRVC, Core C) for The Center for Systems Neurogenetics of
Addiction will serve several interrelated functions. The first will be to provide cohorts of mice for
neurobehavioral screening and biobanking. To accomplish this, the Core will provide expert management of
the breeding capacity for cohorts of Collaborative Cross strains and will also manage the acquisition and
movement of Diversity Outbred (DO) and founder inbred strains from the JAX Repository to the CSNA. The
Core will also provide capacity for variant validation through the creation of novel variants in mouse iPS/ES
cells, in vitro screening of the engineered cell lines for functional testing and, for a subset of promising
functional variants, capacity for in vivo validation through CRISPR/Cas9 technology. The Core will provide
expertise and infrastructure to create new mouse models for gene variants, which will be archived at JAX and
will be made available for distribution to the global research community according to NIH sharing policy and
our resource sharing plan. Finally, the Core will conduct primary research on exciting new tools and
technologies for cloning DO mice with the ultimate goal of developing best practices for functional validation of
extreme, highly polygenetic phenotypes found in the DO genomes. This latter activity will deliver an
unprecedented type of retrievable, but genetically complex addiction models for functional studies and further
genetic and genomic characterization.

## Key facts

- **NIH application ID:** 9933845
- **Project number:** 5P50DA039841-05
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** LAURA G REINHOLDT
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $221,325
- **Award type:** 5
- **Project period:** — → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9933845

## Citation

> US National Institutes of Health, RePORTER application 9933845, Mouse Resources and Validation (5P50DA039841-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9933845. Licensed CC0.

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