# Metabolic Physiology Shared Resource

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $226,384

## Abstract

Metabolic Physiology Shared Resource: Project Summary/Abstract
The Metabolic Physiology Shared Resource (MPSR) provides investigators with a platform for the design,
execution, and interpretation of highly specialized procedures for conducting experiments in vivo. The MPSR
facilitates research for investigators in species spanning from mouse to humans. Many of the basic tenets of
experimental design are species-independent permitting resources and expertise to be pooled under the
common MPSR umbrella. This philosophy alleviates experimental constraints by providing access to a variety
of model systems and provides for seamless translation of basic experimental findings to humans. The MPSR
uses a defined mechanism for the design and optimization of experimental protocols using an established
Studio format. The Studio (i) brings together Vanderbilt scientists with specific expertise to review a proposal;
(ii) identifies potential limitations on the front-end; and (iii) leads to the most efficient use of resources including
animals and human volunteers. The MPSR makes complex in vivo experiments feasible by providing
specialized animal surgical (e.g. catheter placement, bariatric surgery) and experimental (e.g. clamps, energy
balance) services. Advancements in the present cycle have led to the development of bariatric surgery
procedures and expansion of resources for energy balance measurements in animals that parallel procedures
used in human studies conducted by the MPSR. The MPSR has also added a human clamp component. The
addition of these vital services fills out the scope of services leading to comprehensive analyses of insulin
action and energy balance from rodents to large animals to human subjects. MPSR services will channel into
analytical, statistical, and bioinformatics services, thereby enhancing the utility of this resource.

## Key facts

- **NIH application ID:** 9933894
- **Project number:** 5P30DK020593-43
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** KEVIN D NISWENDER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $226,384
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9933894

## Citation

> US National Institutes of Health, RePORTER application 9933894, Metabolic Physiology Shared Resource (5P30DK020593-43). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9933894. Licensed CC0.

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