# Early Peanut Introduction:  Translation to Clinical Practice

> **NIH NIH U01** · JOHNS HOPKINS UNIVERSITY · 2020 · $848,837

## Abstract

Project Summary:  
The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a
major step towards prevention of food allergy. However, because that finding was from a clinical
trial in a very select population, there are several major questions that must be answered in
order to implement these findings into clinical practice without causing more harm than good.
These questions include who, if anyone, should be screened prior to early introduction for
peanut allergy, how this screening should be done, and what quantity of peanut ingestion is
needed to prevent peanut allergy. Our goal is to answer these critical questions so that the
potential of these recent findings can be realized. To that end, we will enroll 400 infants at high-
risk of peanut allergy. These infants will be given a peanut skin prick test, peanut food challenge
and have blood drawn for measurement of peanut IgE, and then will be followed for assessment
of peanut consumption and development of peanut allergy. Aim 1 is to determine the rate of
peanut reactivity in infancy among these high risk groups, Aim 2 is to characterize the
performance of possible screening tests for peanut allergy in infancy, and Aim 3 is to
characterize the peanut consumption patterns of these infants after screening and to determine
the association with development of peanut allergy. Exploratory Aim 4 is to understand
racial/ethnic disparities in risk of reactivity and diagnostic parameters of screening tests.

## Key facts

- **NIH application ID:** 9934102
- **Project number:** 5U01AI125290-05
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Corinne Keet
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $848,837
- **Award type:** 5
- **Project period:** 2016-06-27 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9934102

## Citation

> US National Institutes of Health, RePORTER application 9934102, Early Peanut Introduction:  Translation to Clinical Practice (5U01AI125290-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9934102. Licensed CC0.

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