# Admin-Core

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $169,582

## Abstract

Summary-Administrative Core
Peanut allergy (PA) is common, affecting 2-5% of school-age children in the US. The characteristics of PA vary
widely among individuals, with some reacting to 1/100th of a peanut and others not having symptoms until they
have ingested many peanuts. Symptoms can vary from mild rashes to fatal anaphylaxis. There is no FDA-
approved treatment, and all patients with PA are managed with strict allergen avoidance. Most research on PA
has focused on those with the most exquisite sensitivity to peanut. Immunotherapy trials commonly exclude
subjects with a threshold dose over 1/3 of a peanut (100mg). However, most individuals with PA have higher
thresholds of reaction and are excluded from current research approaches. We hypothesize that the natural
heterogeneity of PA is a valuable opportunity for investigation. We have shown that milk or egg allergic
individuals with tolerance to baked forms of these foods not only tolerate their inclusion in the diet, but this
exposure increases the rate of resolution 14-16-fold. We hypothesize that dietary exposure to sub-threshold
levels of peanut in those with higher threshold levels of reactivity could lead to significant clinical improvement.
Furthermore, studying the natural heterogeneity of PA is a valuable opportunity to elucidate mechanisms of
disease. In this center grant, which uses the “Model B: Clinical Trial” format, we build a program around a
randomized open feeding trial (CAFETERIA trial, Project 1) to investigate a prototype approach where children
with moderate PA (tolerating at least 100 mg of peanut) ingest a sub-threshold amount daily, with increasing
levels tested every 3 months. The impact of dietary intervention will be tested at 1 and 2 years by oral food
challenge. The trial will be administered by the Clinical Core, which will distribute samples to Projects 2 and 3,
for determining the immune and molecular basis of phenotypic heterogeneity in peanut allergy. The Clinical
Core will also house the Data and Statistical Coordinating Center (DSCC). The Administrative Core will
facilitate this program by providing the administrative and organizational structure for this Center, coordinating
interactions within (Projects 1-3 and the Clinical Core) and outside the Center, e.g. with NIAID, other AADCR
Centers, and with the external Scientific Advisory Board. The Administrative Core will provide managerial
support, organizational support for monthly internal project review meetings, quarterly inter-project meetings of
PI's and key personnel, AADCRC Steering Committee teleconferences, Scientific Advisory Board
teleconferences/meetings, and annual AADCRC PI meetings in Bethesda. The Core will arrange lodging,
meeting rooms and equipment for meetings held at Mount Sinai, take and distribute notes from intra-project
and inter-project meetings, and process travel expense reports for scientific meetings and PI, Project PI and
Co-PI’s attendance at annual AADCRC meetings. The Core...

## Key facts

- **NIH application ID:** 9934150
- **Project number:** 5U19AI136053-03
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Cecilia Berin
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $169,582
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9934150

## Citation

> US National Institutes of Health, RePORTER application 9934150, Admin-Core (5U19AI136053-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9934150. Licensed CC0.

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