# Oklahoma COBRE in Structural Biology

> **NIH NIH P20** · UNIVERSITY OF OKLAHOMA · 2020 · $2,112,947

## Abstract

PROJECT SUMMARY (Overall Component)
Structural biology is a multidisciplinary research area that focuses on the important relationship between
macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE)
in Structural Biology (OCSB) was established in 2012 with Phase I funding. The OCSB supports faculty
research projects and three core facilities on the OU-Norman and OU Health Sciences Center campuses for
crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and
purification and biophysical analysis. Structural biology lies at the intersection of many different areas of
biological sciences and thus has the potential of impacting numerous biomedically important fields. The
research projects proposed herein have direct relevance to human diseases and conditions associated with
neurodegenerative diseases, cancer, stroke, and both chronic and acute bacterial infections. The overall
objective of this Phase II application is to continue to build and nurture a critical mass of researchers in
structural biology and support their research programs through shared resources and expertise. The specific
aims of this Phase II application are to: 1) Support and augment the research activities and career
development of junior and early career investigators through senior mentorship and enhanced research
infrastructure with the goal of enhancing their ability to compete successfully for independent external funding;
2) Continue to provide state-of-the-art research core facilities in support of structural biology researchers by
expanding the capabilities of these cores and developing a path to self-sustainability; and 3) Continue to
promote and enhance the visibility of structural biology in the State of Oklahoma through OCSB-sponsored
activities such as annual symposia, workshops, a pilot project program, and undergraduate and graduate
research and education programs.

## Key facts

- **NIH application ID:** 9934233
- **Project number:** 5P20GM103640-09
- **Recipient organization:** UNIVERSITY OF OKLAHOMA
- **Principal Investigator:** ANN H WEST
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,112,947
- **Award type:** 5
- **Project period:** 2012-08-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9934233

## Citation

> US National Institutes of Health, RePORTER application 9934233, Oklahoma COBRE in Structural Biology (5P20GM103640-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9934233. Licensed CC0.

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