# Macromolecular Crystallography Lab

> **NIH NIH P20** · UNIVERSITY OF OKLAHOMA · 2020 · $111,648

## Abstract

PROJECT SUMMARY
(Macromolecular Crystallography Laboratory)
The three-dimensional structure determination of macromolecules such as proteins and nucleic acids using X-
ray crystallography provides unique insights into the function of the molecule or molecular complex. The OU-
Norman Macromolecular Crystallography Laboratory Core (MCL) provides expertise and state-of-the-art
instrumentation to support the Oklahoma COBRE in Structure Biology (OCSB) affiliated research groups and
other research groups involved in structural biology research, particularly in protein crystallography, across the
State of Oklahoma. The MCL accomplishes this by utilizing robotic instrumentation for the screening of
crystallization conditions, the utilization of a high flux micro focus X-ray generator and a state-of-the-art hybrid
pixel X-ray detector for data collection along with up to date maintenance of computational resources to
process and determine the structure of the macromolecules of interest. The MCL director, Dr. Leonard
Thomas, is a full time Ph.D. crystallographer. The facility also employs a Graduate Assistant to aid in the
screening of crystallization conditions and the preparation of samples for collection of X-ray data. The MCL
provides training to students, postdoctoral fellows and faculty who are interested in macromolecular structure
determination. During the OCSB Phase I funding the MCL user base has been greatly expanded and the
facility will continue to expand its user base by providing expertise, state-of-the-art facilities and training during
the OCSB Phase II.

## Key facts

- **NIH application ID:** 9934238
- **Project number:** 5P20GM103640-09
- **Recipient organization:** UNIVERSITY OF OKLAHOMA
- **Principal Investigator:** Leonard M Thomas
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $111,648
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9934238

## Citation

> US National Institutes of Health, RePORTER application 9934238, Macromolecular Crystallography Lab (5P20GM103640-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9934238. Licensed CC0.

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