# Component for Institution # 19-01414

> **NIH NIH P40** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $723,833

## Abstract

This application is a competing renewal of the "Vervet Research Colony as a Biomedical Resource" 
(VRC, P40-OD010965). The VRC is the only NIH-funded biomedical research resource for US-born 
vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded 
since 2005. The VRC serves a wide range of local, regional and national investigators by providing 
animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs 
as multi-categorical, translational models of human disease. Since the previous renewal, the VRC 
has provided resources to over 100 investigators, including over 250 animals and over 1,500 
biological samples, as well as data and consultation. The VRC has also provided the necessary 
infrastructure and technical expertise enabling the on-site use of over 600 animals across 30 
different studies. The VRC has facilitated critical translational research across a wide variety of 
disciplines, including: a) the development of the vervet as an emerging nonhuman primate model of 
Alzheimer's disease risk with a focus on the assessment of amyloid burden, neurodegenerative 
disease biomarkers, and synaptic degeneration; b) investigations into the efficacy and enhancement 
of vaccines for infectious diseases such as neonatal influenza, respiratory syncytial virus, and 
dengue fever; c) studies focused on the etiology and health consequences of diabetes, metabolic 
disease and obesity; d) the development of novel, non-invasive biomedical imaging methodologies; 
and e) the expansion of the critical genetic resources available for vervets, including the 
sequencing of the vervet genome. The aims of the VRC resource are to: 1) provide the scientific 
community with access to animals, biological samples, data and expertise to facilitate the use of 
vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities 
for veterinarians and researchers interested in using vervets for translational research, and to 
serve as a platform for community and scientific outreach to foster better understanding of the use 
of nonhuman primates in biomedical research; and 3) to enhance the resource by engaging in applied 
research focused on continuing genetic and phenotypic characterization of vervets across the 
lifespan and evaluation of the vervet as a potential translational model in novel research areas. 
The VRC is a critical component of the Wake Forest Clinical and Translational Science Award (CTSA), 
which provides administrative support and facilitates the utilization of the VRC resource across 
the larger CTSA network. The VRC is able to take full advantage of a wide-range of existing 
research facilities within the Wake Forest School of Medicine, including multi-modal imaging 
capabilities, veterinary and pathology expertise, and genetic and analytic resources.

## Key facts

- **NIH application ID:** 9934454
- **Project number:** 2P40OD010965-16
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Matthew Jorgensen
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $723,833
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9934454

## Citation

> US National Institutes of Health, RePORTER application 9934454, Component for Institution # 19-01414 (2P40OD010965-16). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9934454. Licensed CC0.

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