# Internal Bonding of Proteins

> **NIH NIH R01** · CORNELL UNIVERSITY · 2020 · $490,595

## Abstract

Project Summary
Our long-term objective is to ascertain how protein conformation plays a role in biological
function and in various diseases. Our specific aims are to combine a new physics-based
method for homology searching, the Property Factor Method (PFM), with our coarse-
grained UNRES potential energy function, and with all-atom potentials, to model several
biological systems related to specific diseases. We will also continue the development of
the PFM approach, with a view to improving the success of homology modeling. We will
demonstrate how these aims can lead to valid predictions of structures and folding
pathways of proteins. Our main focus will involve the application of this methodology to
specific biological problems.

## Key facts

- **NIH application ID:** 9935092
- **Project number:** 5R01GM014312-64
- **Recipient organization:** CORNELL UNIVERSITY
- **Principal Investigator:** Gia Maisuradze
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $490,595
- **Award type:** 5
- **Project period:** 1977-01-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9935092

## Citation

> US National Institutes of Health, RePORTER application 9935092, Internal Bonding of Proteins (5R01GM014312-64). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9935092. Licensed CC0.

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