# Core D: Medicinal Chemistry

> **NIH NIH P20** · UNIVERSITY OF KANSAS LAWRENCE · 2020 · $174,568

## Abstract

SUMMARY 
The development of useful chemical probes generally requires careful optimization of initially discovered agent, 
whether they arise by modifying an existing agent, from high throughput screening or fragment-based 
methods, or through a computational study. The purpose of Core D is to provide synthetic chemistry support, 
including the validation of hit compounds obtained through high-throughput screening, quality control and 
analysis of compounds, synthesis of compounds unavailable commercially but needed by researchers, 
structure-activity relationship studies based on HTS campaigns, and optimization of fragment binders. 
Although most libraries used for screening and fragment efforts will continue to be commercially procured, the 
MC Core will continue ongoing efforts to create novel libraries for screening and fragment work. The work of 
the MC Core will be integrated into the suite of core lab activities. For example, hit selection and clustering will 
be done in conjunction with Cores B and C, compound management and storage in close cooperation with the 
HTS component of Core C, and analog design in collaboration with Core C.

## Key facts

- **NIH application ID:** 9935094
- **Project number:** 5P20GM113117-05
- **Recipient organization:** UNIVERSITY OF KANSAS LAWRENCE
- **Principal Investigator:** Jeffrey Aube
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $174,568
- **Award type:** 5
- **Project period:** 2020-05-01 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9935094

## Citation

> US National Institutes of Health, RePORTER application 9935094, Core D: Medicinal Chemistry (5P20GM113117-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9935094. Licensed CC0.

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