# Core B - Animal Core

> **NIH NIH P01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $352,221

## Abstract

Core B: Animal Core Summary
One of the synergistic aspects of the current Program Project is that all of the individual projects
will evaluate some aspect of their research questions in several common models, e.g.,
intracardiac and intratibial injection of tumor cells. Having common animal models allows us to
rapidly translate findings from one project to another project. Due to the unique nature of bone
compared to soft tissues, many models of bone metastasis are challenging and require special
expertise. The Animal Core has provided extensive service to the Program in the previous
grant cycle. The goal of the Animal Core, which has rated Superior, in previous reviews, is to
continue to provide investigators of each project with assistance in the conduct of research
involving animals including establishment of unique animal models (e.g., vertebral body
implants known as vossicles), intracardiac and intratibial injection, in vivo and ex vivo tumor
imaging and miscellaneous animal procedures. The core has been very successful achieving its
goals and has always rated Superior in reviews. To continue to accomplish support of the
Program the Animal Core has the following Aims:
Aim 1. Creating and assessing animal models to be used for the projects. In addition to
routine animal modeling, we will facilitate use of animal models unique to bone metastasis
research or that are challenging. For example, implantation of vertebrae to create vossicles,
intratibial injections, intracardiac injections and orthotopic implants will be performed by the
Animal Core.
Aim 2. Assisting with animal experiments. Core personnel will coordinate and assist or
instruct in the performance of standardized procedures such as in vivo imaging, intracardiac
injections, compound injections, anesthesia, etc.
Aim 3. Imaging animals. The core will assist with imaging including faxitron radiographs,
bioluminescent imaging, bone density (DEXA) scanning and CT.
Aim 4. Providing expertise in use of animal models and interpretation of data from these
animals. Dr. Evan Keller, a Board-certified veterinary oncologist and Dr. Jill Keller, a Board-
certified laboratory animal veterinarian, will provide expertise in interpretation of animal models
as needed.
Aim 5. Ensuring all animal experiments have appropriate animal compliance. In
collaboration with Administrative core, we will ensure that all experiments are performed under
appropriate institute approval

## Key facts

- **NIH application ID:** 9935672
- **Project number:** 2P01CA093900-16
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Evan T Keller
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $352,221
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9935672

## Citation

> US National Institutes of Health, RePORTER application 9935672, Core B - Animal Core (2P01CA093900-16). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9935672. Licensed CC0.

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