# Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients

> **NIH NIH R01** · UNIVERSITY OF MINNESOTA · 2020 · $732,181

## Abstract

Abstract
The goal of this project is to create a heart valve that can grow with children and never require replacement.
Using a biologically-engineered collagenous matrix in the form of a tube that has been shown to grow as a
pulmonary artery replacement in lambs, and a novel design for a heart valve made from these tubes and
degradable suture that confers durable commissures as well as valve growth potential, we will design,
optimize, test, and implant tri-tube valves in a juvenile sheep model to demonstrate valve growth. Aim 1 will
use computer-aided design (a fluid-structure interaction model for valve opening and finite element model for
the closed valve state) to screen combinations of design parameters (defining coaptation area and geometry)
for efficient valve function, Aim 2 will test the optimal designs in a pulse duplicator and validate/refine the CAD
models, and Aim 3 will involve studies of the valve in growing juvenile sheep. Long-term studies of pulmonary
and aortic valve replacement are designed with measurements to rigorously address valve growth.

## Key facts

- **NIH application ID:** 9935967
- **Project number:** 5R01HL107572-08
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** ROBERT T TRANQUILLO
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $732,181
- **Award type:** 5
- **Project period:** 2011-04-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9935967

## Citation

> US National Institutes of Health, RePORTER application 9935967, Completely biological tissue-engineered pulmonic valve grown in vitro from human cells for pediatric patients (5R01HL107572-08). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9935967. Licensed CC0.

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