This application requests R13 funding to support the Annual Meeting of the Society for Prevention Research (SPR), and activities closely related to the Annual Meeting, for five years (2017—2021). The Society for Prevention Research (SPR) was established in 1991 and has catalyzed the growth of the prevention science. The strength of SPR and its relevance to the transdisciplinary field of prevention science, national policy and practice has been new discoveries, new methods, and integration of research and knowledge from multiple fields. SPR's goal is improving the science of prevention across all aspects of physical and mental health and social well-being. Further, SPR strives to foster the development of new methodologies and statistical tools to improve the learning from longitudinal studies and prevention trials. The cutting-edge research and scientific advancements discussed at the Annual Meeting support the achievements of the more than 800 members of SPR, and catalyze the improvement of public health and well-being. Research featured at the SPR Annual Meeting focuses on epidemiology and prevention of a variety of behavioral health problems including the use of alcohol, tobacco, and other drugs, violence, early pregnancy and sexually transmitted infections, mental health problems, and physical health problems including obesity and cancers. Research also focuses on the promotion of healthy outcomes, including issues related to maternal, infant, and child health, social/emotional development, and academic achievement. The Annual Meeting, which now draws more than 800 attendees per year, fills an important role in promoting prevention science as a transdisciplinary field, bringing together scientists to promote cross- fertilization of theory, methods, and intervention with the goal of building the science of effective strategies for health promotion and prevention. The meeting features science that directly addresses a number of critical needs raised in the NIH Roadmap Science of Behavior Change Meeting, including: (1) the use of multilevel approaches and understanding the effects of environmental contexts; (2) the use of approaches that target multiple outcomes and behaviors; (3) research informed by a developmental perspective, (4) research to better understand the mechanisms underlying behavior change; and (5) research on the development, dissemination, and use of innovative methods. Further, the meeting and SPR's new 5-year Strategic Plan have synergy with many NIH initiatives including precision medicine, big data, and integrating biological and neurological discoveries into prevention innovations. The Specific Aims of the current application build on the progress in the field of prevention science, prior annual meetings, work of SPR committees and workgroups and on the SPR's five-year strategic planning process. These specific aims are: (1) To continuously develop an integrated scientific forum for the exchange of new concepts, method...