# Biological functions of beta herpesvirus encoded non-coding RNAs

> **NIH NIH R21** · UPSTATE MEDICAL UNIVERSITY · 2020 · $202,500

## Abstract

Project Abstract:
Human cytomegalovirus (HCMV) and Human Herpesvirus 6a (HHV6a) members of the β-herpesvirus family,
are pathogens that have evolved to infect a significant majority of the human population. Both viruses retain
the capacity to reactivate from latency, which is highly problematic in immunosupressed populations. These
two viruses encode numerous factors that undermine host responses to viral infection and alter the subcellular
environment thereby promoting efficient viral replication. This proposal seeks to define the biological role for
the microRNAs (miRNAs) encoded by these two viruses. We will evaluate the requirement of each miRNA as
well as utilize novel and innovative techniques for RNA and protein labeling within viral infected cells.
Successful completion of these aims will fill a significant knowledge gap in our understanding of the viral
factors that promote pathogenesis.

## Key facts

- **NIH application ID:** 9936155
- **Project number:** 5R21AI147152-02
- **Recipient organization:** UPSTATE MEDICAL UNIVERSITY
- **Principal Investigator:** Eain A Murphy
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $202,500
- **Award type:** 5
- **Project period:** 2019-06-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9936155

## Citation

> US National Institutes of Health, RePORTER application 9936155, Biological functions of beta herpesvirus encoded non-coding RNAs (5R21AI147152-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9936155. Licensed CC0.

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