# Catalytic C-C Activation of Ketones - Renewal 01

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2020 · $306,244

## Abstract

Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C)
bond activation for developing new, general and synthetically useful methods. Our objective, in
the proposed funding period, is to focus on C−C activation of ketones, as ketone moieties are
ubiquitously found in feedstock chemicals, synthetic building blocks and bioactive compounds.
Specifically, we will: (i) expand the scope and utilities with activation of strained ketones for
constructing complex ring systems, (ii) enable new and broadly applicable transformations with
unstrained ketones in an atom-economical fashion, and (iii) explore a new activation mode that
can shift the paradigm for ketone activation. The research proposed is expected to simplify
synthesis through new strategic bond disconnections, allow for editing skeletons of complex
molecules under redox-neutral conditions, and offer a byproduct-free approach to access
organic building blocks.

## Key facts

- **NIH application ID:** 9936172
- **Project number:** 5R01GM109054-07
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Guangbin Dong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $306,244
- **Award type:** 5
- **Project period:** 2013-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9936172

## Citation

> US National Institutes of Health, RePORTER application 9936172, Catalytic C-C Activation of Ketones - Renewal 01 (5R01GM109054-07). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9936172. Licensed CC0.

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