This application is a competitive renewal of our long-standing Cardiovascular Research (CVR) Training Program. As a top 20 public Research I University, the University of Arizona (UA) has a proven track record of mentoring, research and collaborations across traditional departmental, college and institutional boundaries. In the last 3 years, the UA has seen an unprecedented focus on heart, vascular and lung research – bringing numerous new faculty to this renewal application, substantive key improvements in infrastructure, and opportunities for our trainees to gain true translational experiences. The current application continues the tradition of developing young investigators for successful biomedical careers via multidisciplinary training at the pre- and postdoctoral levels. Forty-four faculty with well-funded collaborative research programs provide strength in 3 broad areas: 1) Molecular Basis of Cardiac Function, 2) Signaling in Vascular and Pulmonary Diseases, and 3) Cardiovascular and Pulmonary Diseases – Molecules to Treatments. Molecular, cellular, and systems approaches are complemented by computational/modeling, proteomics/metabolomics/genomics, biophysical, nanotech and advanced imaging approaches. Extensive support from the UA, state-of-the-art core facilities, and opportunities for underrepresented minority researchers (e.g., UA is top of all Research I institutions for URMs in graduate school) rounds out a unique and outstanding research environment for training future leaders in Cardiovascular Biomedical Research. The CVR program is adaptable to the specific needs and interests of each trainee. Predoctoral trainees receive a broad background in biomedical sciences as well as exposure to interdisciplinary research, multiple experimental approaches, and practical and ethical aspects of careers in science. Predoctoral candidates also develop presentation and intrapersonal skills through an active student forum, journal clubs, MD/PhD colloquium and a “meet the speaker” seminar program. The postdoctoral training plan ensures that trainees foster a comprehensive path towards independence by expanding their research focus, learning new state-of-the-art techniques and career skills particularly in grant/manuscript preparation. All trainees attend national and international meetings and participate in symposia featuring the trainees' research. The maturation of the CVR Program incorporates a robust training plan to integrate predoctoral, postdoctoral, MD/PhD and clinical trainees to align with the NIH mission of T32 translational research training. Translational experiences are enhanced via active participation in weekly clinical (Cardiology or Pulmonary Fellow) conferences. The newly developed Arizona Institute for Clinical and Translational Science together with the new infusion of resources and projects via our NIH Precision Medicine Initiative Cohort Program, offers all trainees unique opportunities to integrate with clinical medicine. ...