# The PREDICT Study (PRE-ICU Determinants of Post-ICU FunCTional Outcomes among Older Adults)

> **NIH NIH K76** · YALE UNIVERSITY · 2020 · $224,244

## Abstract

PROJECT SUMMARY/ABSTRACT
Candidate: My career goal is to become an independent physician-scientist and national leader in geriatric
critical care outcomes research whose body of work improves the long-term functional outcomes of critically ill
older adults. My clinical training as a Pulmonary & Critical Care Medicine (PCCM) physician and research
training in Geriatric Clinical Epidemiology have prepared me to pursue this career path. My track record of
early success is evidenced by the publication of high-impact original reports and the receipt of 3 grants,
including a GEMSSTAR award. I have already distinguished myself as a national leader in my specialty as well
as in geriatrics: I founded and am co-chair of the American Thoracic Society Critical Care Assembly's Aging
and Geriatrics Working Group, and was recently selected as an incoming co-chair of the American Geriatrics
Society (AGS) Medical Subspecialties Section. My research efforts have been recognized nationally, with the
AGS New Investigator Award, and at Yale, with the prestigious Iva Dostanic Physician-Scientist Award.
Mentors and Environment: I have an exceptional team of mentors and advisors, including my primary mentor
Dr. Thomas Gill (Geriatrics), a leading expert on the epidemiology and prevention of disability, co-mentor Dr.
Margaret Pisani (PCCM), an expert in critical care outcomes research, and advisor Dr. Terrence Murphy, a
biostatistician with expertise in longitudinal studies of aging and critical care outcomes research. My research
and career development plans draw on the wealth of resources available at Yale, including the Yale Program
on Aging/Claude D. Pepper Older Americans Independence Center, the Yale School of Public Health, and one
of the largest intensive care units (ICUs) in the country at Yale-New Haven Hospital. These resources, and the
support provided by the Section of Pulmonary, Critical Care, and Sleep Medicine at the Yale School of
Medicine, provide an ideal environment for my career development and execution of the proposed research.
Mentored Research Project: Nearly 1.4 million older adults survive an ICU stay each year, and many of these
will suffer from increased disability. Our prior work has demonstrated that premorbid factors are strongly
associated with the course of disability after a critical illness – yet no mechanism exists to identify which older
ICU patients are at risk of increased disability. To address this knowledge gap, I have proposed an innovative
research project that leverages the wealth of resources available at Yale in addition to two high-quality
longitudinal datasets: the National Health and Aging Trends Study (NHATS) and Precipitating Events Project
(PEP). The overall objective is to develop, externally validate, and pilot test a predictive tool (that incorporates
premorbid risk factors) to identify older ICU patients at risk of worsening post-ICU disability and provide a
personal estimate of the increase in disability. The res...

## Key facts

- **NIH application ID:** 9936412
- **Project number:** 5K76AG057023-04
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Lauren Ferrante
- **Activity code:** K76 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $224,244
- **Award type:** 5
- **Project period:** 2017-08-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9936412

## Citation

> US National Institutes of Health, RePORTER application 9936412, The PREDICT Study (PRE-ICU Determinants of Post-ICU FunCTional Outcomes among Older Adults) (5K76AG057023-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9936412. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*