# CRCNS: Collaboration toward an experimentally validated multiscale model of  rTMS

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 2020 · $164,885

## Abstract

Mental health diseases such as depression are a major burden on society and new treatment options are strongly needed. One strategic goal of NIMH is to develop novel therapies based on discoveries in neuroscience. TMS is a non-invasive neuromodulation technique that can directly interfere with brain activity. TMS is FDA-approved for depression treatment, however, shows mixed efficacy. Thus, improved stimulation protocols would have a major impact in providing better treatments for depression and other brain diseases associated with alterations in cortical excitability (e.g., autism, schizophrenia). Here, we propose to develop a multiscale model of rTMS that will combine electric field simulations with neuron models and molecular simulations of intracellular calcium. Accompanying experiments in in-vitro slice preparations will be used to validate model predictions.

## Key facts

- **NIH application ID:** 9936450
- **Project number:** 5R01MH118930-03
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Gillian Queisser
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $164,885
- **Award type:** 5
- **Project period:** 2018-07-09 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9936450

## Citation

> US National Institutes of Health, RePORTER application 9936450, CRCNS: Collaboration toward an experimentally validated multiscale model of  rTMS (5R01MH118930-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9936450. Licensed CC0.

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