# Hyperoxia-induced KV channel regulation in an aging mouse model

> **NIH NIH R15** · UNIVERSITY OF SOUTH FLORIDA · 2020 · $430,649

## Abstract

Project Summary:
Cardiovascular diseases are major cause of deaths in United States and Worldwide. According to the American
Heart Association (AHA), more than 2200 deaths reported every day with an average of 1 in every 39 seconds.
Arrhythmias and cardiomyopathy is also reported in many diseased conditions including acute lung injury,
diabetes, obesity, hypertension and cancer. Patients in critical care or intensive care unit (ICU) are often
administered with hyperoxia (PaO2 > 100 mmHg) for treatment with acute lung injury, congestive heart failure,
cardiac fibrosis. However, recent studies indicate that dysfunctional lung and compromised pulmonary
functioning cause increased workload on the heart and therefore lead to cardiac remodeling resulting in
arrhythmias, heart failure and death. Among all the ventilated patients, early estimates of mortality rates in
mechanical ventilation was as high as 40-45%. Additionally, existing reports suggests that more than 50% of the
population admitted to ICU are older adults with ages more than 60 years. Studies also reported significantly
higher in-hospital mortality in older adult population in ICU than younger population without differences in the
duration of mechanical ventilation. The exact nature of this problem remains unknown. In this study we will
investigate the genes involved in ventricular remodeling and electrical remodeling in hyperoxia induced aged
(older adult) mice hearts using molecular, and biochemical methods and compared with young adult mice. These
changes will be further investigated for their roles in physiological changes occur in aged mice heart using
echocardiography, ECG and whole-cell patch-clamping techniques and will be compared with young adult mice.
Our preliminary data also suggests that exposure of mice to hyperoxia for 24h is enough to initiate cardiac
remodeling. Therefore, in this proposal we will identify the optimum time of exposure for hyperoxia at which most
of the pathophysiology induced by hyperoxia in aged mice hearts can be reversed. We will also investigate the
molecular mechanisms of ventricular remodeling and electrical remodeling in hyperoxia conditions, knowing
which not only important to understand the disease development and progression, but also to develop targeted
therapy for the disease cure.

## Key facts

- **NIH application ID:** 9936988
- **Project number:** 1R15AG064674-01A1
- **Recipient organization:** UNIVERSITY OF SOUTH FLORIDA
- **Principal Investigator:** Siva Kumar Panguluri
- **Activity code:** R15 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $430,649
- **Award type:** 1
- **Project period:** 2020-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9936988

## Citation

> US National Institutes of Health, RePORTER application 9936988, Hyperoxia-induced KV channel regulation in an aging mouse model (1R15AG064674-01A1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/9936988. Licensed CC0.

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