# Einstein Aging Study

> **NIH NIH P01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $421,857

## Abstract

This renewal application in response to the National Institute of Aging program announcement:
AR-16-359 NIA – Revision and Resubmission Program Project Applications proposes the
addition of a new, one-year project to the Einstein Aging Study program project (NIH/NIA: P01
AG03949). Since 1993, the EAS has been a population based longitudinal study of older
individuals residing in Bronx, New York. The program project has long focused on risk factors
and cognitive changes that predict the subsequent onset of dementia, particularly Alzheimer’s
disease (AD). The proposed work will expand the scope of EAS in a new direction by adding
metabolite data related to the exposures of interest in the existing program project. The value of
this work is that these new measures and/or a selected combination thereof may serve as early
markers for the identification of high risk individuals, and elucidation of potential intervention
targets for AD. This will be achieved by leveraging the EAS database and biorepository which
contain detailed longitudinal assessments and serial bio-specimens from over 2,200 individuals
who have been recruited and followed by the study. These resources will be used to conduct a
nested case-control study of incident AD cases and closely matched, cognitively normal controls
identified based on longitudinal EAS data. The proposed project will allow us to refine and
target a panel of metabolites related to AD risk using an efficient study design and state of the
art metabolomics approaches. The long-term goal is to extend this proposed work to examine
the association of the identified metabolites with novel ambulatory indicators of cognitive change
currently being collected in the EAS projects. The ongoing EAS has an overarching goal of
improving the detection of early cognitive change by using advances in ambulatory cognitive
assessments that reduce intra-individual variability and improve sensitivity for detecting change.
The current projects are currently recruiting and following a new sample of 600 individuals who
are completing novel ambulatory cognitive assessments annually. In keeping with this theme,
the proposed new project will expand the science of the EAS in a new direction and will lay the
foundation for assessing serum biomarkers in individuals who are currently completing annual
ambulatory cognitive assessments to determine whether metabolites that predict incident AD
may be used to identify individuals at risk for early cognitive decline prior to AD onset.

## Key facts

- **NIH application ID:** 9937198
- **Project number:** 3P01AG003949-37S1
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Richard B. LIPTON
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $421,857
- **Award type:** 3
- **Project period:** 1982-09-29 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9937198

## Citation

> US National Institutes of Health, RePORTER application 9937198, Einstein Aging Study (3P01AG003949-37S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9937198. Licensed CC0.

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