# Core B: Mouse Aging Analysis Core

> **NIH NIH P01** · YALE UNIVERSITY · 2020 · $561,356

## Abstract

Core B: Project Summary:
The objective of Core B (Mouse Aging Analysis Core ) is to provide a centralized core facility for the PPG at
the Yale School of Medicine that will generate and analyze transgenic mouse models to determine the roles of
FGF21 on lifespan extension and age-related functional decline across multiple systems. The Core B will
allow the PPG to gain mechanistic insights into the pro-longevity effects of FGF21 across multiple organ
systems (adipose tissue, liver, bone, CNS and the immune system) using measures of functional decline in
aging, longevity and burden of disease as primary endpoints. The Aim 1 of Core B is be work closely with the
leader of the Administrative Core and leaders of the research projects, to assist in the experimental design and
execution of the animal research phase of the individual projects, and to assure efficiency and standardization
of procedures. The Aim2 is To perform an omnibus study with male and female mice examining the effect of
inducible overexpression of FGF21 on lifespan and the contribution of adiponectin to FGF21's pro-longevity
effect. Aim 3: To determine the cause of death by detailed pathologic examination of inducible FGF21Tg mice
and inducible FGF21Tg mice lacking adiponectin. These studies will involve gross necropsies and histological
analyses to quantify pathology and disease burden in our mouse models. Dr. Caroline Zeiss (ACVP and
ACLAM boarded) will direct these studies as part of the PPG team. The aim4 will perform an omnibus study
with male and female mice examining the role of the FGF21-adiponectin endocrine axis on healthspan and
age-related functional decline across organ systems.

## Key facts

- **NIH application ID:** 9938384
- **Project number:** 5P01AG051459-05
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** VISHWA DEEP DIXIT
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $561,356
- **Award type:** 5
- **Project period:** — → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9938384

## Citation

> US National Institutes of Health, RePORTER application 9938384, Core B: Mouse Aging Analysis Core (5P01AG051459-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9938384. Licensed CC0.

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