# Program Integration and Management

> **NIH NIH P01** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $7,907

## Abstract

Abstract
The Program Integration and Management component of this Program Project will assure communication
among the Projects and Cores so that each Project and Core is able to conduct their own research and to
interface among the others. Furthermore, this component will assure the responsible management of the
Projects and Cores of the Program Project. As noted, the 3 projects with a laboratory component will use DNA
or RNA from the exact same tumors. The Administrative Core has been responsible for developing the
collaborations in order to obtain tumors and will maintain the harmonized data (see Appendix x), with the
critical information as to Stage at diagnosis, year of diagnosis and follow up with survival information (Dead of
Melanoma, Dead of Other Causes, and Alive at Follow up); the Biospecimen Core will receive the tumors,
evaluate them for histopathologic characteristics (see Biospecimen Core), such as Breslow thickness, solar
elastosis, tumor infiltrating lymphocytes (TILs), etc., send the H&E to UNC for Aperio ScanScope scanning to
share with all investigators, extract DNA and RNA from each tumor, as well as uninvolved normal tissue (in
cases where we don’t have germline DNA from blood or lymph nodes), send DNA to Project 1 for targeted
mutation analysis (both tumor and germline, including evaluation of CNVs), send DNA to Project 2 for
methylation assays, and send RNA to Project 3 for analysis of microRNA and mRNA using Nanostring. The
Bioinformatics Core will develop tools for storage, management and sharing data generated by individual
projects. It will also assist each project in analysis beyond the “pipeline” analyses that will be available for the
IMPACT assay and the methylation assays, as well as the miRNA and mRNA analyses. These data will be
available to Project 4 as will the raw data from each project, so that the Integration can occur as described.
Progress in each project will be monitored during the bi-weekly Teleconferences as the PI’s of each project
(Berwick, Thomas, Hernando-Monge and Shen) and core (Berwick, Thomas, Busam and Gorlov) are on the
Steering Committee along with several key members (Armos, Begg, Ernstoff and Orlow). We have established
a strong trusting relationship among the individuals and difficult issues have already been worked out and so
we anticipate continuation of these excellent interactions.

## Key facts

- **NIH application ID:** 9938486
- **Project number:** 5P01CA206980-04
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** MARIANNE BERWICK
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $7,907
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9938486

## Citation

> US National Institutes of Health, RePORTER application 9938486, Program Integration and Management (5P01CA206980-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9938486. Licensed CC0.

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