# Pulmonary Toxicology Facility Core

> **NIH NIH P30** · UNIVERSITY OF IOWA · 2020 · $296,913

## Abstract

PROJECT SUMMARY – PULMONARY TOXICOLOGY FACILITY
The overarching goal of the Pulmonary Toxicology Facility (PTF) is to provide the facilities and expertise for
investigators to enhance the productivity and quality of their pulmonary toxicology research and to assist them
in exploring new investigative areas in asthma, pulmonary biology, inhalation toxicology, and aerosol science.
Investigators are also supported with expertise and assays to evaluate exposures to rural airborne toxicants,
asthma triggers and microorganism-associated molecular patterns such as bacterial endotoxin and fungal
glucans in environmental epidemiology studies. The PTF is an extremely productive and highly interactive
facility that plays an indispensable role in advancing rural environmental health and the Thematic Areas, Pilot
Grant Program and Career Development Program of the EHSRC. Through rigorous and transformative
research, the PTF expands the body of knowledge on inhaled toxicants applying innovative exposure systems
and methodology. The PTF conducts studies to elucidate adverse outcome pathways for inhaled
environmentally-relevant toxicants and multipollutant mixtures. The PTF has the equipment and staff expertise
to provide investigators with validated methods and authenticated biological reagents for addressing novel
hypotheses regarding pulmonary exposures, lung biology and biological response profiles. The PTF provides
services free of charge to recipients of EHSRC pilot grants and Associate Members receiving salary support
from the Career Development Program. Other EHSRC Members, NIEHS intramural researchers and members
of NIEHS-funded centers at other institutions receive discounted rates. The institutional commitment to the
facility is spectacular with a $2,286,280 commitment for newly renovated facilities in the heart of the biomedical
campus plus additional instrumentation. In the current cycle, the PTF has served 83 investigators on 81
projects with 46,304 exposure and biomarker assays, 1,426 experimental animals, 990 toxicology procedures,
and has deployed and received 8,479 field samplers. Six specific aims will be addressed in the proposed
scope of work: Aim 1) Provide expertise and facilities for the use of animal models to elucidate adverse
outcome pathways of xenobiotics or to test novel inhalation therapies; Aim 2) Design and perform inhalation
exposure studies to groups of laboratory animals under rigidly controlled exposure conditions; Aim 3) Assess
biomarkers and sensitive physiologic endpoints to identify biological response profiles, low-dose functional
changes, and susceptibility factors; Aim 4) Provide high-content in vitro studies using pulmonary epithelial cells
exposed at the air-liquid interface; Aim 5) Perform exposure assessment of endotoxins, glucans, allergens, and
metagonomics of microbial communities in support of epidemiologic studies of environmental lung diseases;
and Aim 6) Facilitate pre-doctoral, post-doctoral and Associate M...

## Key facts

- **NIH application ID:** 9938558
- **Project number:** 5P30ES005605-30
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Peter S Thorne
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $296,913
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9938558

## Citation

> US National Institutes of Health, RePORTER application 9938558, Pulmonary Toxicology Facility Core (5P30ES005605-30). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9938558. Licensed CC0.

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