# Biacore T200 Surface Plasmon Resonance Spectroscopy

> **NIH NIH S10** · RENSSELAER POLYTECHNIC INSTITUTE · 2020 · $343,946

## Abstract

Summary
Title: Biacore T200 Surface Plasmon Resonance Spectroscopy
Surface plasmon resonance (SPR) spectroscopy is a powerful instrument to measure
biomolecular interactions in real-time and a label free environment. SPR has been
applied to characterize the binding events with samples ranging from proteins, nucleic
acids, carbohydrates, small molecules to complex mixtures, lipid vesicles, viruses, bacteria,
and eukaryotic cells. This project is a Shared Instrumentation Grant Program (S10)
application entitled “Biacore T200 Surface Plasmon Resonance Spectroscopy”. The Biacore
T200 is a versatile, label-free system for detailed studies of biomolecular interactions
delivering high quality kinetic, affinity and thermodynamic interaction data in real time with
exceptional sensitivity. The system will be very useful in fundamental biological studies,
health/clinic science research, drug discovery, environmental and biopharmaceutical
process monitoring for large groups of researchers in our Center for Biotechnology &
Interdisciplinary Studies (CBIS). A Biacore 3000 instrument currently housed in CBIS has
reached the end of its useful life with the discontinuation of this instrument model. This
instrument was used in over 100 research studies examining protein-protein, protein-
glycan, glycan-glycan, protein-lipid, protein-DNA, DNA-DNA, protein-nanoparticle
interactions published by CBIS faculty from 2004-2019. Many CBIS research groups will
use the more sensitive and higher throughput Biacore T200 SPR to study the molecular
interactions with important physiological significance in signaling and developmental biology
and pathophysiological significance, including ones related to cancer, kidney disease,
infectious disease, and Alzheimer’s disease. The data from SPR analysis will provide a
deeper understanding of many of the biochemical pathways and networks.

## Key facts

- **NIH application ID:** 9939054
- **Project number:** 1S10OD028523-01
- **Recipient organization:** RENSSELAER POLYTECHNIC INSTITUTE
- **Principal Investigator:** ROBERT J LINHARDT
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $343,946
- **Award type:** 1
- **Project period:** 2020-09-16 → 2021-09-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939054

## Citation

> US National Institutes of Health, RePORTER application 9939054, Biacore T200 Surface Plasmon Resonance Spectroscopy (1S10OD028523-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9939054. Licensed CC0.

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