# 4.7T MRI for Translational Research Animal Facility

> **NIH NIH S10** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2020 · $1,997,103

## Abstract

Project Summary
We are proposing to obtain a Bruker Biospin Advance Neo 47/40 USR pre-clinical MR imaging system with
Paravision 360 software, including a 4.7T (Tesla) 40 cm magnet, gradient and shim coils (main and upgraded
one for rodents), gradient/shim cooling, RF amplifiers, shim amplifier, Faraday cage, several RF volume and
planar surface coils. For the proposed application, the major projects consist of 19 funded NIH projects (14 NIH
R01 projects, a NIH R21 project, 4 NIH P20 funded projects), as well as 2 Dept. of Defense (DoD) projects, and
a Veteran Affairs (VA) project; as well as 5 minor projects (4 NIH R01 projects, and one VA project), primarily
from The University of Oklahoma Health Sciences Center ( OUHSC), Oklahoma Medical Research Foundation
(OMRF), Oklahoma State University (OSU), the Hough Ear Institute, The University of Oklahoma (Norman
campus), and the VA Medical Center, that will all directly benefit from the proposed preclinical MRI equipment.
The proposed 47/40 USR magnet, Advance Neo hardware and Paravision 360 will allow researchers in
Oklahoma and the region to obtain fast, non-distorted imaging data for oncological, neurological,
cardiac/cardiovascular, infectious diseases and bone-related investigations. The projects range in biomedical
research from oncology studies – lung, pancreatic, ovarian, melanomas, and general tumor biology;
neurological diseases – septic encephalopathy, myopia, mild traumatic brain injury, stress-induced chronic
pain, neurovascular dysfunction, and hearing impairment; cardiac/cardiovascular diseases – tachycardia, and
cardiovascular aging; infectious diseases – zika virus, herpes simplex virus, bacillus endophthalmitis, and
clostridium difficile; to bone-related diseases – osteoarthritis. Experimental animal species to be investigated
include mice, rats, gerbils, guinea pigs, rabbits, chinchillas, swine (mini), dogs and non-human primates. The
proposed equipment will significantly enhance the biomedical imaging and translational preclinical research that
for Oklahoma biomedical research institutions.

## Key facts

- **NIH application ID:** 9939252
- **Project number:** 1S10OD028495-01
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Dee H Wu
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,997,103
- **Award type:** 1
- **Project period:** 2020-08-15 → 2024-08-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939252

## Citation

> US National Institutes of Health, RePORTER application 9939252, 4.7T MRI for Translational Research Animal Facility (1S10OD028495-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9939252. Licensed CC0.

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