# Re-entry XR-NTX for rural opioid dependent women

> **NIH NIH R34** · UNIVERSITY OF KENTUCKY · 2020 · $186,920

## Abstract

ABSTRACT
The overall aim of this R34 proposal is to examine the feasibility, acceptability, and short-term outcomes
associated with an innovative service delivery model to increase adherence to extended-release naltrexone (XR-
NTX) during the transition from jail to the community for rural women with opioid use disorder (OUD). The
significance of this study is grounded in the public health crisis associated with the opioid epidemic in rural
Appalachia, the increased vulnerability of rural women with OUD, and the dearth of available and accessible
evidence-based treatment in the region. This R34 has potential to make a significant contribution to the OUD
treatment field by advancing knowledge on innovative service delivery models to increase access to evidence-
based treatment to reduce high-risk opioid use and related health disparities among hard-to-reach, high-risk,
underserved populations. The study will be accomplished through two specific aims: (1) Adapt XR-NTX services
for use in community supervision (P&P) offices to increase adherence during re-entry from jail for rural women
with OUD. (2) Examine feasibility, acceptability, and short-term outcomes of XR-NTX adherence and relapse to
opioid use through a small pilot trial with 60 rural women with OUD. The pilot trial will include OUD screening,
medical evaluation, XR-NTX initiation prior to jail release, and random assignment to one of two community re-
entry treatment models to receive on-going XR-NTX injections in the community after release in either: (1) A
local rural P&P office (n=30), or (2) Services as Usual (n=30, referral to a community clinic). If this study
establishes feasibility of this innovative community-based treatment model for XR-NTX in a rural, underserved
area, findings will be used to develop an R01 application to test the approach in a larger RCT during community
re-entry from jail among high-risk rural women with OUD in Appalachia. The long-term goal of this research is to
increase access to evidence-based treatment for OUD among high-risk, underserved populations.

## Key facts

- **NIH application ID:** 9939501
- **Project number:** 5R34DA045856-03
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Michele Staton
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $186,920
- **Award type:** 5
- **Project period:** 2018-09-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939501

## Citation

> US National Institutes of Health, RePORTER application 9939501, Re-entry XR-NTX for rural opioid dependent women (5R34DA045856-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9939501. Licensed CC0.

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