# Core B - Hauser

> **NIH NIH P01** · DUKE UNIVERSITY · 2020 · $468,595

## Abstract

Biostatistics and Bioinformatics Core (“Core B”/Core 001)
PROJECT SUMMARY
This Core is responsible for providing expertise in data management, data quality control, and multivariate,
structural and clinical modeling to the Projects. The overall Program, developed over 25 years of NHLBI
support, has generated a significant amount of data, results, analyses and manuscripts that identify
interactions between genetic variation, psychosocial stress, behavioral and physiological endophenotypes, in
pathways to cardiometabolic disease and adverse clinical course. Likewise, the number of datasets
contributing to these activities and the number of individuals in these datasets has increased over time such
that in the renewal period we propose work on very large datasets. The Biostatistics Core is responsible for the
smooth management and availability of those data to the projects. Continued advances in genome sciences
have resulted in a vast expansion of the resources and tools available to identify the genetic determinants of
complex cardiometabolic diseases. Our prior work has demonstrated that it is critical to include the effects of
environmental stressors (G x E) in these analyses. Dissecting the genetic basis of these traits requires not only
technological advances, but also access to well-characterized study populations that have appropriate
environmental measures. In addition, the modeling of G x E effects requires integrated statistical
methodologies and expertise in the biology and epidemiology of these traits. To provide seamless integration
and a high-level of informatics support members of Core B participate as Project team members as well as
participate in Core activities. The Aims of the Biostatistics and Bioinformatics Core are:
1) To facilitate the four Projects in this PPG by providing data management and data quality control as needed
for all aspects of the Program;
2) To provide advice and support for statistical analysis, computer programming and bioinformatics to the
Projects;
3) To coordinate integrated analyses that cross two or more Projects.

## Key facts

- **NIH application ID:** 9939627
- **Project number:** 5P01HL036587-29
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Elizabeth R Hauser
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $468,595
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939627

## Citation

> US National Institutes of Health, RePORTER application 9939627, Core B - Hauser (5P01HL036587-29). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9939627. Licensed CC0.

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