# ERK signaling in arteriogenesis

> **NIH NIH P01** · YALE UNIVERSITY · 2020 · $539,385

## Abstract

Project Summary
 The development and formation of normal and abnormal vasculature is of critical importance
to both normal biology and disease pathogenesis. Vascular homeostasis plays an important role
in maintenance of normal vessel and organ function. Recent studies from our and other
laboratories have established that ERK1/2 (extracellular receptor kinases 1 and 2) are critical to
these processes. Yet there is a very limited understanding of what these kinases do and how
this is accomplished.
 We propose to determine relative contributions of ERK1 vs. ERK2 to arterial fate specification
and arteriogenesis, establish key steps in regulation of the ERK activity, discovery downstream
signaling pathways, and decipher functional effects of ERK1 vs. ERK2 signaling.
 In preliminary studies we have observed abnormal arteriogenesis in mice missing the ERK1
isoform and abnormal angiogenesis in mice missing the ERK2 isoform. These data point to
unexpected specificity of these kinases’ activity that open a possibility of selectively targeting
these two processes. The ability to do so would be of tremendous clinical significance.

## Key facts

- **NIH application ID:** 9939658
- **Project number:** 5P01HL107205-08
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Michael Simons
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $539,385
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939658

## Citation

> US National Institutes of Health, RePORTER application 9939658, ERK signaling in arteriogenesis (5P01HL107205-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9939658. Licensed CC0.

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