# Clinical Core

> **NIH NIH P01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $405,829

## Abstract

Clinical Core Abstract
The human core developed through the first 4 years has become an established center for translational
research in pulmonary hypertension (PH), encompassing a large biorepository and clinical trials coordinating
center. The goal of the human core during this renewal is to support all Research Projects by 1) providing the
infrastructure and expertise necessary to conduct clinical trials of new therapies of dietary supplements for
Group I and Group II PH, and 2) collecting hemodynamic, clinical, biomarker, and microbiome data on PH
patients for robust phenotyping. Specific expansions of the human core for this renewal include enrollment of
Groups I-V PH patients into the human subphenotyping core registry to provide mechanistic insight into endo-
phenotypes of PH including the role of the microbiome in PH, collection of pulmonary artery endothelial cells
during clinical right heart catheterization, as well as harvest of isolated endothelial, smooth muscle and lung
fibroblasts from human lungs of PH patients removed at time of transplantation. The core will draw on the
extensive clinical and research infrastructure harnessed during the first phase of the TPPG including 14 clinics,
over 1,000 clinical right heart catheterization each year, 34 ongoing NIH- or industry-funded research projects,
over 2,500 biospecimens banked, a vascular clinical translational research center specializing in assessment
of endothelial function for 9 NIH- or industry-funded research projects, and over 1,200 patients enrolled in
clinical trials over the past five years. The human core is critical to all Projects to fulfill the translational directive
of the TPPG, in which each Project will conduct a clinical or translational trial. This unmatched resource will
accelerate the pace of discovery in the Projects by rapidly identifying appropriate patients for clinical trials and
by providing a wealth of biospecimens with corresponding clinical data for mechanistic investigations.

## Key facts

- **NIH application ID:** 9939662
- **Project number:** 5P01HL103455-10
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** MARC A SIMON
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $405,829
- **Award type:** 5
- **Project period:** 2011-06-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9939662

## Citation

> US National Institutes of Health, RePORTER application 9939662, Clinical Core (5P01HL103455-10). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9939662. Licensed CC0.

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