# HIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICE

> **NIH NIH S10** · WASHINGTON UNIVERSITY · 2020 · $377,860

## Abstract

PROJECT SUMMARY/ABSTRACT
 This proposal requests support for the purchase of a VisualSonics Vevo 3100 Imaging Platform, which
will be used for structural and functional analysis of the cardiovascular system in experimental animal models
of common human cardiovascular diseases. It will be housed and operated in the Mouse Cardiovascular
Phenotyping Core facility of the Center for Cardiovascular Research at Washington University School of
Medicine. This dedicated in vivo micro-imager will markedly advance the capabilities of the Cardiovascular
Phenotyping Core, which has been for over 20 years, a highly successful, large volume Core facility,
performing thousands of echocardiographic studies and surgical procedures annually. The Core has served
numerous researchers from a wide variety of disciplines across multiple departments and schools at
Washington University, as well as nationwide. Indeed, the users’ work depends on the availability of high-
quality echocardiographic analysis. As a result of the quality and success of the research projects of the Core
investigators, there has been a steady rise in the volume and complexity of the echocardiographic studies over
the years. This has brought us to the point that the existing system can no longer adequately satisfy the
demands of the User Group on the scale and scope that is required for the scientific needs of each participant.
There is now a compelling scientific need and a pressing logistical demand to replace the old and outdated
system.
 The VisualSonics Vevo 3100 is a highly versatile ultrasound platform capable of providing researchers
with the ability to visualize and quantify small animal anatomical targets, hemodynamics, and therapeutic
interventions with resolution down to 30 microns. Its state-of-the-art technical features are uniquely suited for
cardiovascular phenotyping in genetically manipulated mice. An upgrade to the new ultrasound system will
provide immediate benefit to the Core users in accomplishing the scientific goals of their NIH funded projects.

## Key facts

- **NIH application ID:** 9940080
- **Project number:** 1S10OD028597-01
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** ATTILA KOVACS
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $377,860
- **Award type:** 1
- **Project period:** 2020-09-18 → 2021-09-17

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940080

## Citation

> US National Institutes of Health, RePORTER application 9940080, HIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICE (1S10OD028597-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9940080. Licensed CC0.

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