# 500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical Research

> **NIH NIH S10** · STANFORD UNIVERSITY · 2020 · $708,762

## Abstract

PROJECT SUMMARY
Stanford Chemistry, Engineering & Medicine for Human Health (ChEM-H) is a new Institute bringing together
chemists, engineers, biologists, and clinicians to understand life at the molecular level and to apply that
knowledge to improving human health. ChEM-H builds on Stanford's extraordinary talent in the Schools of
Humanities & Sciences, Engineering, and Medicine, as well as from the SLAC National Accelerator
Laboratory, to explore this new frontier at the interface of chemistry and human biology. In this proposal we
request funds from the NIH High End Instrumentation (HEI) S10 Grant Program to purchase a new Bruker
Avance Neo 500 MHz NMR Spectrometer with High-Sensitivity CryoProbe and Automated Sample
Changer to be sited in the brand-new and centrally located Stanford ChEM-H Building, part of the new ChEM-
H / Neuro research complex. The instrument will be accessible and enabling to all researchers at Stanford.
Nuclear Magnetic Resonance (NMR) spectroscopy is the single most important routine characterization
technique for scientists working in chemistry or at an interface therewith. However, current NMR capabilities
on campus are severely limited by the existence of outdated instruments that lack the ability to quickly analyze
samples on sub-milligram scales and to do so in a high-throughput manner. Updating current instrumentation
is critical to the future research at ChEM-H and across the university. We are requesting the acquisition of a
state-of-the-art Bruker NMR system in order to bring much needed modern molecular characterization abilities
to campus. A high sensitivity CryoProbe to be included with this acquisition will make possible previously
unavailable experiments such as the ability to acquire on low-concentration samples in a reasonable period
of time. The requested automated sample changer will dramatically increase the quantity of possible data
acquisition by allowing routine experiments to be run unattended around the clock. Overall, the new
instrument will be enabling for current and future studies of chemical systems that need to be analyzed and
characterized by research groups that include ligands, small molecules, natural products, extracts, inhibitors,
drugs, derivatives, tool compounds, libraries, as well as their interrogation within larger molecules (proteins,
nucleic acids, polymers, etc.) of interest to ChEM-H and Stanford faculty. The long-term goal of ChEM-H is
to explore the biological chemistry frontier in order to better understand human biological systems and to treat
disease. In order to achieve this objective, it is critical that NMR capabilities at Stanford are updated through
the acquisition of a modern instrument.

## Key facts

- **NIH application ID:** 9940156
- **Project number:** 1S10OD028697-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Noah Zachary Burns
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $708,762
- **Award type:** 1
- **Project period:** 2020-08-15 → 2022-02-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940156

## Citation

> US National Institutes of Health, RePORTER application 9940156, 500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical Research (1S10OD028697-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9940156. Licensed CC0.

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