# Small Animal High Resolution Metabolic Analysis System

> **NIH NIH S10** · JOSLIN DIABETES CENTER · 2020 · $573,318

## Abstract

Project Summary/Abstract
The numbers of people with diabetes and prediabetes are increasing rapidly within the United
States and throughout the world. People with diabetes possess significant risks of developing
severe health complications, which create enormous social, economic, and psychological
burdens to society. Joslin Diabetes Center is the world leader in managing and treating this
devastating disease and is committed to advance research in discovering and developing
preventative treatments, new therapies, and ultimately cure diabetes. One of the essential and
powerful techniques required for the diverse diabetes research is metabolic phenotyping. In this
application, we request funds to support the purchase of the Promethion Core High Definition
Metabolic Phenotyping System for metabolic studies in mice from Sable Systems International.
The Sable Promethion system is a non-invasive, high resolution comprehensive real-time lab
animal monitoring system with environmental chamber, exercise wheel, stable isotope analyzer,
and germ-free caging that enable advanced metabolic and behavioral characterization of mouse
physiology. The Promethion instrument is being requested through this application in order to
replace the current older Comprehensive Lab Animal Monitoring System that has been used to
its maximum capacity continuously for the past 13 years and to add new features to advance
research projects that utilize this instrumentation. The proposed instrument will be used by at
least 19 major and minor labs at Joslin and institutions in the surrounding research community.
More than 95% of the committed users are currently funded by Federal grants. The instrument
will support research projects focused on insulin actions, insulin resistance, growth factor
signaling, adipocyte biology, nutrient utilization, molecular mechanisms of exercise, epigenetics,
islet biology, vascular function, microbiomes, cancer, aging, and others. This instrument will be
housed in the Animal Physiology Core facility of Joslin’s NIH-funded Diabetes Research Center
and will be maintained by one full-time technician and the Core manager. The addition of the
Sable Promethion System to Joslin’s Animal Physiology Core will not only fulfill the critical need
for technologically advanced instrumentation of metabolic phenotyping but also significantly
increase the quantity of high quality of metabolic studies performed by users of the Joslin
Animal Physiology Core. It will ultimately lead to discoveries that pave the ways to develop new
approaches for the prevention and treatment of diabetes and its complications.

## Key facts

- **NIH application ID:** 9940315
- **Project number:** 1S10OD028568-01
- **Recipient organization:** JOSLIN DIABETES CENTER
- **Principal Investigator:** Yu-Hua Tseng
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $573,318
- **Award type:** 1
- **Project period:** 2020-09-16 → 2022-09-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940315

## Citation

> US National Institutes of Health, RePORTER application 9940315, Small Animal High Resolution Metabolic Analysis System (1S10OD028568-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9940315. Licensed CC0.

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