# BIACORE T200 SPR FOR NOTRE DAME BIOPHYSICS INSTRUMENTATION CORE (BIC) FACILITY

> **NIH NIH S10** · UNIVERSITY OF NOTRE DAME · 2020 · $342,782

## Abstract

PROJECT SUMMARY
Characterization of biomolecular interactions is a crucial pre-requisite to understanding biological functions on
a molecular level. Surface plasmon resonance (SPR) has been an essential component of the biophysical tool
kit for decades, providing fundamental information about the interactions between various types of
biomolecules, including information about kinetics, affinities, specificity, and underlying thermodynamic
quantities. Currently, a state-of-the-art SPR instrument is not broadly available to University of Notre Dame
researchers. In response to Program Announcement PAR-19-179, this proposal requests funds to purchase a
Biacore T200 SPR system to further the research goals of Notre Dame scientists. The NIH-funded researchers
will use the T200 for a variety of projects, including understanding and improving specificity in cellular
immunity, characterizing the bacterial cell wall degradome, characterize the interaction of pathogenic bacteria
with host cells and designing small molecule inhibitors of molecular chaperones with anti-cancer and
neuroprotective effects. This instrument will fulfill an urgent need for access to a shared SPR instrument at
Notre Dame. To ensure broad access, the new instrument will be housed in the centrally-located, newly
established Biophysics Instrumentation Core (BIC) Facility, where new user training, general operations and
upkeep will be overseen by a PhD-level staff scientist. The proposed instrument represents one piece of a
large effort currently underway to expand and improve research infrastructure at Notre Dame.

## Key facts

- **NIH application ID:** 9940404
- **Project number:** 1S10OD028553-01
- **Recipient organization:** UNIVERSITY OF NOTRE DAME
- **Principal Investigator:** Brian M Baker
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $342,782
- **Award type:** 1
- **Project period:** 2020-07-10 → 2021-07-09

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940404

## Citation

> US National Institutes of Health, RePORTER application 9940404, BIACORE T200 SPR FOR NOTRE DAME BIOPHYSICS INSTRUMENTATION CORE (BIC) FACILITY (1S10OD028553-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9940404. Licensed CC0.

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