# System for Synthesis of PET Radiopharmaceuticals

> **NIH NIH S10** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $592,500

## Abstract

The Gordon Center for Medical Imaging PET Core is a Partners Healthcare System service core located at
Massachusetts General Hospital, which operates a FDA registered, cGMP PET radiopharmaceutical
manufacturing facility to supply clinical research and pre-clinical research studies. The Gordon PET Core has
over 20 PET radiopharmaceuticals available for human research studies which enable over 100 active clinical
research protocols, including over 40 NIH-funded protocols, to conduct PET imaging research at MGH. The
volume of clinical research studies has over the past 10 years has dramatically increased. The huge demand
from investigators is associated with a large increase of NIH funded studies involving PET imaging that has
created a current scheduling lead time of over 8 weeks. The Core PET radiochemistry synthesis units are
currently running at maximum capacity.
An increase in the manufacturing capacity of C-11 and F-18 PET radiopharmaceuticals through the addition of
new synthesis units and associated lead lined hot cell is needed to address the demands from NIH-funded
research studies for investigational PET drugs. The proposed instrumentation would have substantial benefit
to all the funded NIH projects listed in our application as well as other institutional users and new investigators
seeking NIH funding.

## Key facts

- **NIH application ID:** 9940418
- **Project number:** 1S10OD026987-01A1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Georges El Fakhri
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $592,500
- **Award type:** 1
- **Project period:** 2020-08-15 → 2022-12-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940418

## Citation

> US National Institutes of Health, RePORTER application 9940418, System for Synthesis of PET Radiopharmaceuticals (1S10OD026987-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9940418. Licensed CC0.

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