# Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for Metabolomics

> **NIH NIH S10** · MONTANA STATE UNIVERSITY - BOZEMAN · 2020 · $599,278

## Abstract

MSU's Proteomics, Metabolomics and Mass Spectrometry Facility (PMMSF) is currently seeking funds to
purchase an Ultra-High performance Liquid Chromatography – Tandem Mass Spectrometry system (UPLC-
MS/MS) for metabolomics research. The current MS system is heavily used, 10 years old, and no longer can
generate leading-edge ultra-high resolution data. Metabolomics involves the global analysis of biological small
molecules, and is one of the most rapidly developing areas in biological research. Largely driven by
technological innovations, the ability of detect and monitor 1000s of biomolecules at the same time is
transforming the way drugs are developed, diseases are categorized, and agriculture practices are
approached. MSU is a strong player in the field of metabolomics research due to our success at securing
external funding for state-of-the-art instrumentation, a strong institutional commitment to support research core
facilities, and an overwhelming enthusiasm from faculty to integrate metabolomics in their research programs.
We are one of only a handful of academic institutions in the USA that have integrated NMR and mass
spectrometry for metabolomics, not only in terms of compatible instrumentation but also in terms of
synergistic, intellectual collaborations between NMR and MS research groups. Recent NSF and Murdock
awards for acquisition of an integrated LC-SPE-NMR/MS instrumentation platform has helped MSU become
the regional leader in metabolomics. Enthusiasm for metabolomics is university wide. Currently, faculty from
Mechanical Engineering, Plant Sciences, Animal and Range Sciences, Land Resources and Environmental
Sciences, Health and Human Development, Center for Biofilm Engineering, Chemical and Biological
Engineering, Microbiology and Immunology, Mathematics, Cell Biology and Neuroscience, and Chemistry and
Biochemistry are involved in metabolomics research. Demand for mass spectrometry-based metabolomics
analyses is already the largest sector of research activities in the MSU Proteomics, Metabolomics, and Mass
Spectrometry Facility and continues to expand. In addition, this instrument will serve as a regional instrument
for researchers in the western IDeA states and Puerto Rico. To maintain and enhance our metabolomics
resources, we are thus requesting a leading edge UPLC-MS/MS instrument that can keep MSU on the
forefront of metabolomics research excellence. Specific advantages of the requested instrument include
higher mass accuracy, faster collection of fragmentation data, molecular shape profiling, and integrated
software for compound identification, which remains a major challenge in the field.

## Key facts

- **NIH application ID:** 9940591
- **Project number:** 1S10OD028650-01
- **Recipient organization:** MONTANA STATE UNIVERSITY - BOZEMAN
- **Principal Investigator:** BRIAN P BOTHNER
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $599,278
- **Award type:** 1
- **Project period:** 2020-09-20 → 2021-09-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9940591

## Citation

> US National Institutes of Health, RePORTER application 9940591, Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for Metabolomics (1S10OD028650-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9940591. Licensed CC0.

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